Current perspectives on vaccines and therapeutics for Lassa Fever.

Autor: Warner BM; Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada. brw566@usask.ca.; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, Canada. brw566@usask.ca., Safronetz D; Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada., Stein DR; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Canada.; Cadham Provincial Laboratory, Winnipeg, Canada.
Jazyk: angličtina
Zdroj: Virology journal [Virol J] 2024 Dec 19; Vol. 21 (1), pp. 320. Date of Electronic Publication: 2024 Dec 19.
DOI: 10.1186/s12985-024-02585-7
Abstrakt: Lassa virus, the cause of deadly Lassa fever, is endemic in West Africa, where thousands of cases occur on an annual basis. Nigeria continues to report increasingly severe outbreaks of Lassa Fever each year and there are currently no approved vaccines or therapeutics for the prevention or treatment of Lassa Fever. Given the high burden of disease coupled with the potential for further escalation due to climate change the WHO has listed Lassa virus as a priority pathogen with the potential to cause widespread outbreaks. Several candidate vaccines have received support and have entered clinical trials with promising early results. This review focuses on the current state of vaccine and therapeutic development for LASV disease and the potential of these interventions to advance through clinical trials. The growing burden of LASV disease in Africa highlights the importance of advancing preclinical and clinical testing of vaccines and therapeutics to respond to the growing threat of LASV disease.
Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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