Effects of probiotics in elderly hospitalized tube-fed patients with antibiotics use.

Autor: Hsia CH; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, 11031, Taiwan, ROC.; Department of Dietetics, Taipei Medical University Hospital, Taipei, 11031, Taiwan, ROC.; Nutrition Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan, ROC., Su HY; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, 11031, Taiwan, ROC.; Department of Dietetics, Taipei Medical University Hospital, Taipei, 11031, Taiwan, ROC.; Nutrition Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan, ROC., Chen YH; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, 11031, Taiwan, ROC.; School of Food Safety, Taipei Medical University, Taipei, 11031, Taiwan, ROC.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 11031, Taiwan.; Research Center of Food Safety Inspection and Function Development, Taipei Medical University, Taipei, 11031, Taiwan, ROC., Chuang HC; Department of Infectious Disease, Taipei Medical University Hospital, Taipei, 11031, Taiwan, ROC., Chien YW; School of Nutrition and Health Sciences, Taipei Medical University, Taipei, 11031, Taiwan, ROC. ychien@tmu.edu.tw.; TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 11031, Taiwan. ychien@tmu.edu.tw.; Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, 11031, Taiwan, ROC. ychien@tmu.edu.tw.; Nutrition Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan, ROC. ychien@tmu.edu.tw.; Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei, 11031, Taiwan, ROC. ychien@tmu.edu.tw.
Jazyk: angličtina
Zdroj: BMC gastroenterology [BMC Gastroenterol] 2024 Dec 19; Vol. 24 (1), pp. 467. Date of Electronic Publication: 2024 Dec 19.
DOI: 10.1186/s12876-024-03561-9
Abstrakt: Background: Several studies revealed the beneficial effects of probiotics against the incidence of antibiotic-associated diarrhea of hospitalized patients but it is rarely to assess the nutrition status. This study investigated the effects of probiotics in elderly hospitalized tube-fed patients with antibiotics use and is the first study that concerns the nutritional status among these patients.
Methods: Elderly hospitalized tube-fed patients who were using antibiotics were recruited. Probiotics were given within 48 h after their first antibiotic therapy, and then twice daily 2 h after consuming antibiotics and a meal; the probiotics were continued to use for an additional 7 days after completion of antibiotics therapy. Anthropometric data, laboratory data, medication records, nutritional status, nutrition intake and data on stool form were collected.
Results: Twenty-nine patients served as probiotic group. 11 patients completed the study in both groups. In probiotic group, the stool form was found to exhibit no significant differences between the beginning and end of antibiotics therapy (5.5 ± 0.8 vs 5.1 ± 1.1, p = 0.21), but the stool frequency significantly decreased (2.0 ± 1.0 vs 1.6 ± 0.7, p = 0.05). In control group, the stool form between the beginning and end of antibiotics therapy exhibited significant improvement (5.6 ± 1.4 vs 4.5 ± 1.4, p = 0.01), but not in the frequency (2.7 ± 2.1 vs 2.4 ± 1.5, p = 0.1). The initial NRS 2002 score of the probiotic and control groups were similar. (3.6 ± 1.7 vs 3.7 ± 1.8, p = 1.00), and their nutrition status both significantly improved during the last visit before discharged (2.6 ± 0.9 vs 2.9 ± 1.3).
Conclusion: Probiotic supplementation in elderly hospitalized tube-fed patients significantly reduced stool frequency during antibiotic treatment. Improvements in stool form were observed only during the follow-up period. Nutritional status remained stable, with patients' nutritional needs adequately met throughout the study.
Competing Interests: Declarations. Ethics approval and consent to participate: This study was approved by all researchers and the local ethics committee, Taipei Medical University-Joint Institutional Review Board (N202008008). All participants provided written informed consent prior to participation. Consent for publication: Not applicable. Competing interests: "The datasets used and/or analzsed during the current study are available from the corresponding author on reasonable request." manuscript.
(© 2024. The Author(s).)
Databáze: MEDLINE
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