Transforming agents: The power of structural modifications in glioblastoma multiforme therapy.

Autor: Norollahi SE; Cancer Research Center and Department of Immunology, Semnan University of Medical Sciences, Semnan, Iran; Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran., Morovat S; Department of Medical Genetics and Molecular Biology, School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran., Keymoradzadeh A; Department of Neurosurgery, School of Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Hamzei A; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Modaeinama M; Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Soleimanmanesh N; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Soleimanmanesh Y; School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Najafizadeh A; School of Paramedicine Sciences, Guilan University of Medical Sciences, Rasht, Iran., Bakhshalipour E; School of Paramedicine Sciences, Guilan University of Medical Sciences, Rasht, Iran., Alijani B; Department of Neurosurgery, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran., Samadani AA; Guilan Road Trauma Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran; Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran. Electronic address: a.a.hormoz@gmail.com.
Jazyk: angličtina
Zdroj: Progress in biophysics and molecular biology [Prog Biophys Mol Biol] 2024 Dec 17; Vol. 195, pp. 41-56. Date of Electronic Publication: 2024 Dec 17.
DOI: 10.1016/j.pbiomolbio.2024.12.001
Abstrakt: Glioblastoma (GBM) is a very deadly type of brain tumor with a poor prognosis and a short survival rate. Recent advancements in understanding GBM's molecular and genetic characteristics have led to the development of various therapeutic and diagnostic strategies. Key elements such as microRNAs, lncRNAs, exosomes, angiogenesis, and chromatin modifications are highlighted, alongside significant epigenetic alterations that impact therapy and diagnosis. Despite these advancements, molecular classifications have not improved patient outcomes due to intratumoral diversity complicating targeted therapies. In this article, it is tried to emphasize the potential of investigating the epigenetic landscape of GBM, particularly identifying patients with diffuse hypermethylation at gene promoters associated with better outcomes. Integrating epigenetic and genetic data has enhanced the identification of glioma subtypes with high diagnostic precision. The reversibility of epigenetic changes offers promising therapeutic prospects, as recent insights into the "epigenetic orchestra" suggest new avenues for innovative treatment modalities for this challenging cancer. In this review article, we focus on the roles of translational elements and their alterations in the context of GBM diagnosis and therapy.
Competing Interests: Declaration of competing interest Hope you are doing well. By the way, I submitted this manuscript which is entitled: The effects of structural modifications of translational agents on the Glioblastoma multiforme in this journal. Importantly, due to the serious sanctions of the USA, we are not able to transfer the money. and request a full waiver for APC. I would be so grateful if you would consider my request. Thank you so much for your deep understanding and attention.
(Copyright © 2024. Published by Elsevier Ltd.)
Databáze: MEDLINE
Externí odkaz: