Assessing azithromycin's ecological toll: Unveiling multifaceted impacts on Poecilia reticulata THROUGH biomarker analysis.

Autor: Marinsek GP; Santa Cecília University (UNISANTA), Santos, SP, Brazil. Electronic address: gabriela.marinsek@unesp.br., Tagliamento MA; São Paulo State University (UNESP), Bioscience Institute, São Vicente, SP, Brazil., Oliveira ICCDS; São Paulo State University (UNESP), Bioscience Institute, São Vicente, SP, Brazil., Capaldo A; University of Naples Federico II, Department of Biology, Naples, Italy., Gusso-Choueri PK; Santa Cecília University (UNISANTA), Santos, SP, Brazil., Ribeiro CC; São Paulo State University (UNESP), Bioscience Institute, São Vicente, SP, Brazil., Feitosa ACC; São Paulo State University (UNESP), Bioscience Institute, São Vicente, SP, Brazil., Abessa DMS; São Paulo State University (UNESP), Bioscience Institute, São Vicente, SP, Brazil., Oliveira MA; São Paulo State University (UNESP), Bioscience Institute, São Vicente, SP, Brazil., Mari RB; São Paulo State University (UNESP), Bioscience Institute, São Vicente, SP, Brazil.
Jazyk: angličtina
Zdroj: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2024 Dec 17; Vol. 113, pp. 104617. Date of Electronic Publication: 2024 Dec 17.
DOI: 10.1016/j.etap.2024.104617
Abstrakt: This study investigates the impact of environmentally relevant concentrations of azithromycin on Poecilia reticulata, through biomarkers at different levels. To this end, the somatic indexes of P. reticulata were evaluated, and liver and gill samples were collected and analyzed for biochemical and histopathological alterations. Azithromycin caused significant effects in P. reticulata, such as increased hepatosomatic index, altered redox responses, particularly in gills, indicating oxidative stress, and notable tissue damage in the liver and gills in a dose-dependent response manner. Principal Component Analysis highlighted differences between control and exposed groups, demonstrating the azithromycin's influence on organismal homeostasis. This research underscores the importance of understanding azithromycin action in nontarget organisms of aquatic environments.
Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Renata de Britto Mari reports financial support was provided by São Paulo State University. Denis Moledo de Souza Abessa reports was provided by São Paulo State University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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