How can MSI enhance our understanding of ASO distribution?

Autor: van der Vloet L; The Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands., Hilaire PBS; Institut de Recherche et Développement Servier Paris-Saclay, Rue Francis Perrin, 91190 Gif-sur-Yvette, France., Bouillod C; Institut de Recherche et Développement Servier Paris-Saclay, Rue Francis Perrin, 91190 Gif-sur-Yvette, France., Isin EM; Institut de Recherche et Développement Servier Paris-Saclay, Rue Francis Perrin, 91190 Gif-sur-Yvette, France., Heeren RMA; The Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands. Electronic address: r.heeren@maastrichtuniversity.nl., Vandenbosch M; The Maastricht MultiModal Molecular Imaging (M4I) institute, Division of Imaging Mass Spectrometry (IMS), Maastricht University, Universiteitssingel 50, 6229 ER Maastricht, the Netherlands.
Jazyk: angličtina
Zdroj: Drug discovery today [Drug Discov Today] 2024 Dec 17; Vol. 30 (1), pp. 104275. Date of Electronic Publication: 2024 Dec 17.
DOI: 10.1016/j.drudis.2024.104275
Abstrakt: In the dynamic field of drug discovery and development, a comprehensive understanding of drug absorption, distribution, metabolism, excretion, and toxicity is crucial. Mass spectrometry imaging (MSI) has become a key analytical tool in the pharmaceutical industry, allowing evaluation of drug biodistribution and molecular profiles. Antisense oligonucleotides (ASOs) are emerging drug candidates for treating neurologic diseases. This review explores the potential of MSI in investigating ASOs' spatial distribution within neurological disease models. Here, we focus on multimodal molecular imaging to gain insights into ASO distribution, simultaneously with a better understanding of the molecular pathways affected by ASOs. An improved understanding of therapeutic ASOs in tissue will potentially improve neurologic therapies, emphasizing their importance in patient care.
(Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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