Simulating a travel-related origin of Candida auris in New York-New Jersey.

Autor:	Verma RR; Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, USA., Kiegle E; Wadsworth Center Mycology Laboratory, New York State Department of Health, Albany, New York, USA., Keyel AC; Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.; Department of Atmospheric and Environmental Sciences, University at Albany, Albany, New York, USA., Chaturvedi S; Wadsworth Center Mycology Laboratory, New York State Department of Health, Albany, New York, USA.; Department of Biomedical Sciences, School of Public Health, University at Albany, Albany, New York, USA., Chaturvedi V; Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, USA.; Department of Pathology, Westchester Medical Center, Valhalla, New York, USA.
Jazyk:	angličtina
Zdroj:	Microbiology spectrum [Microbiol Spectr] 2024 Dec 19, pp. e0206524. Date of Electronic Publication: 2024 Dec 19.
DOI:	10.1128/spectrum.02065-24
Abstrakt:	Candida auris first appeared in the United States in 2013 in New York-New Jersey (NY-NJ) and led to an unprecedented outbreak since 2016. We hypothesized C. auris ' introduction to NY-NJ was not a random event but related to travel patterns between South Asia and NY-NJ. New York City is a US hub for international passengers, including those from South Asia. We tested the hypothesis by simulating introductions to NY-NJ with a Monte Carlo simulation based on travel from South Asia, proportion of US population in NY-NJ, proportion of hospitals in NY-NJ, and finally, proportion of all travelers entering the United States through NY-NJ. The C. auris outbreak occurred during increasing travel and trade, and South Asia travel routes predict the distribution of early C. auris cases in NY-NJ. The local mobility network within hospitals and extended stay healthcare facilities were also relevant in the spread of C. auris . Our observations and simulations link travel patterns to C. auris origin and spread and warrant further investigations for understanding the continued spread of the pathogen. Importance: Candida auris is an emerging fungal pathogen, with resistance to several antifungal drugs. Serious C. auris infections affect hospitalized patients and residents of long-term care facilities, although the pathogen can also be present on a healthy individual's skin. Many studies have shown international introductions of C. auris to the United States. Here, we present a simulation that supports the hypothesis that the earlier introductions of C. auris in the New York-New Jersey area are not random but related to travel networks.
Databáze:	MEDLINE
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