Fel d 1 specific IgE measurement for dog exclusive owners co-sensitized to dog and cat.
| Autor: | Liang L; Graduate School of Medicine, Yonsei University College of Medicine, Seoul, South Korea.; Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea., Hwang AR; Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea., Shin YJ; Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea., Jeong KY; Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea., Park KH; Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea.; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea., Lee JH; Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea.; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea., Park JW; Institute of Allergy, Yonsei University College of Medicine, Seoul, South Korea.; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | The World Allergy Organization journal [World Allergy Organ J] 2024 Dec 02; Vol. 17 (12), pp. 101007. Date of Electronic Publication: 2024 Dec 02 (Print Publication: 2024). |
| DOI: | 10.1016/j.waojou.2024.101007 |
| Abstrakt: | Background: The diagnosis of the culprit allergen depends on exposure, symptoms at exposure, and the presence of specific IgE (sIgE). Pet allergens are sticky and can sensitize individuals without adoption history. Exclusive dog owners frequently exhibit both dog (e5) and cat dander sIgE (e1). We assessed whether the measurement of Fel d 1 sIgE (e94) can discriminate true cat sensitization from false positivity by cross-reactivity in the exclusive dog owners. Methods: Thirty-one patients with respiratory allergies who exclusively owned dogs were enrolled for this study. e5, e1, and e94 were measured with ImmunoCAP. ELISA inhibition was performed to assess cross-reactivity. Results: About 81% of patients (25/31) were both e5 and e1 positive, and 8 were also positive for e94. In the e94 positive, cat dander exhibited higher maximum inhibition of cat sIgE (94% vs 88%) and demonstrated lower IC Conclusions: Genuine co-sensitization to cats is notable even in individuals who exclusively own dogs. Positive e94 results could discriminate authentic cat sensitization from false positivity by cross-reactivity in these patients, underscoring the importance of comprehensive allergy assessment. Competing Interests: The authors have no potential conflicts of interest to disclose. (© 2024 The Author(s).) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|