Independent and Interactive Impacts of Prenatal Exposure to Legal Substances and Childhood Trauma on Emotion Processing in Pre-Adolescents: Preliminary Findings From the ABCD Study.

Autor:	Lepow L; Icahn School of Medicine at Mount Sinai, New York, New York.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Wagner A; Icahn School of Medicine at Mount Sinai, New York, New York.; Tufts University School of Medicine, Boston, Massachusetts., Peri S; Icahn School of Medicine at Mount Sinai, New York, New York., Adams F; Icahn School of Medicine at Mount Sinai, New York, New York., Ramakrishnan SA; Icahn School of Medicine at Mount Sinai, New York, New York.; Rutgers University, New Brunswick, New Jersey., Alam MA; Centers for Outcomes and Health Services Research, Ochsner Health, New Orleans, Louisiana., Shaik RB; Icahn School of Medicine at Mount Sinai, New York, New York., Hubbard NA; University of Nebraska-Lincoln, Lincoln, Nebraska., Koenigsberg HW; Icahn School of Medicine at Mount Sinai, New York, New York., Hurd Y; Icahn School of Medicine at Mount Sinai, New York, New York.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Tapert SF; University of California, San Diego, California., Ivanov I; Icahn School of Medicine at Mount Sinai, New York, New York., Parvaz MA; Icahn School of Medicine at Mount Sinai, New York, New York.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Jazyk:	angličtina
Zdroj:	JAACAP open [JAACAP Open] 2024 Jul 04; Vol. 2 (4), pp. 274-289. Date of Electronic Publication: 2024 Jul 04 (Print Publication: 2024).
DOI:	10.1016/j.jaacop.2024.04.009
Abstrakt:	Objective: This paper investigated the effects of prenatal drug exposure (PDE), childhood trauma (CT), and their interactions on the neurobiological markers for emotion processing. Method: Here, in a non-clinical sample of pre-adolescents (9-10 years of age) from the Adolescent Brain Cognitive Development (ABCD) Study (N = 6,146), we investigate the impact of PDE to commonly used substances (ie, alcohol, cigarettes, and marijuana), CT, and their interaction on emotion processing. From the Emotional N-back functional magnetic resonance imaging task data, we selected 26 regions of interests, previously implicated in emotion processing, and conducted separate linear mixed models (108 total) and accounted for available environmental risk factors. Results: PDE was associated with reductions in response bias related to the processing of fearful compared to happy faces in widespread cortical regions (including the superior frontal and fusiform gyri and the inferior parietal lobule). Reduced response bias in the superior frontal gyrus emerged as PDE driven and was present regardless of CT status, but correlated with several items on the Child Behavior Checklist only in those children with both PDE and CT. The lower response bias of the left inferior parietal lobule, on the other hand, was observed only in children with both PDE and CT, and correlated with internalizing and externalizing behaviors. Conclusion: The study's results support the diathesis-stress model, and suggest that PDE may confer vulnerability to the effects of later CT through altered neurodevelopment. Children experiencing these "double-hit" conditions may represent at-risk individuals who could benefit from early interventions to mitigate the onset of psychopathology. Because of limitations in the way that PDE was reported in the ABCD Study, including lack of severity measures and retrospective reporting, results are not sufficient for making recommendations or dictating policy for pregnant persons. Nevertheless, this study is a necessary first step in examining the interactive effects of prenatal and early-life exposures, as well as many aspects of the sociodemographic and psychological environment. (© 2024 The Author(s).)
Databáze:	MEDLINE
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