Feasibility of relaxation along a fictitious field in the 2nd rotating frame (T RAFF2 ) mapping in the human myocardium at 3 T.

Autor:	Tourais J; Imaging Physics, Delft University of Technology (TU Delft), Delft, Netherlands.; Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Božić-Iven M; Imaging Physics, Delft University of Technology (TU Delft), Delft, Netherlands.; Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Zhao Y; Imaging Physics, Delft University of Technology (TU Delft), Delft, Netherlands., Tao Q; Imaging Physics, Delft University of Technology (TU Delft), Delft, Netherlands., Pierce I; Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.; Institute of Cardiovascular Science, University College, London, United Kingdom., Nitsche C; Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.; Institute of Cardiovascular Science, University College, London, United Kingdom., Thornton GD; Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.; Institute of Cardiovascular Science, University College, London, United Kingdom., Schad LR; Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Mannheim Institute for Intelligent Systems in Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Treibel TA; Barts Heart Centre, Barts Health NHS Trust, London, United Kingdom.; Institute of Cardiovascular Science, University College, London, United Kingdom., Weingärtner S; Imaging Physics, Delft University of Technology (TU Delft), Delft, Netherlands., Akçakaya M; Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States.; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Dec 04; Vol. 11, pp. 1373240. Date of Electronic Publication: 2024 Dec 04 (Print Publication: 2024).
DOI:	10.3389/fcvm.2024.1373240
Abstrakt:	Purpose: Evaluate the feasibility of quantification of Relaxation Along a Fictitious Field in the 2nd rotating frame (RAFF2) relaxation times in the human myocardium at 3 T. Methods: T RAFF 2 mapping was performed using a breath-held ECG-gated acquisition of five images: one without preparation, three preceded by RAFF2 trains of varying duration, and one preceded by a saturation prepulse. Pixel-wise T RAFF 2 maps were obtained after three-parameter exponential fitting. The repeatability of T RAFF 2 , T 1 , and T 2 was assessed in phantom via the coefficient of variation (CV) across three repetitions. In seven healthy subjects, T RAFF 2 was tested for precision, reproducibility, inter-subject variability, and image quality (IQ) on a Likert scale (1 = Nondiagnostic, 5 = Excellent). Additionally, T RAFF 2 mapping was performed in three patients with suspected cardiovascular disease, comparing it to late gadolinium enhancement (LGE), native T 1 , T 2 , and ECV mapping. Results: In phantom, T RAFF 2 showed good repeatability (CV < 1.5%) while showing no ( R 2 = 0.09 ) and high ( R 2 = 0.99 ) correlation with T 1 and T 2 , respectively. Myocardial T RAFF 2 maps exhibited overall acceptable image quality (IQ = 3.0 ± 1.0) with moderate artifact levels, stemming from off-resonances near the coronary sinus. Average T RAFF 2 time across subjects and repetitions was 79.1 ± 7.3 ms. Good precision (7.6 ± 1.4%), reproducibility (1.0 ± 0.6%), and low inter-subject variability (10.0 ± 1.8%) were obtained. In patients, visual agreement of the infarcted area was observed in the T RAFF 2 map and LGE. Conclusion: Myocardial T RAFF 2 quantification at 3 T was successfully achieved in a single breath-hold with acceptable image quality, albeit with residual off-resonance artifacts. Nonetheless, preliminary clinical data indicate potential sensitivity of T RAFF 2 mapping to myocardial infarction detection without the need for contrast agents, but off-resonance artifacts mitigation warrants further investigation. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (© 2024 Tourais, Božić-Iven, Zhao, Tao, Pierce, Nitsche, Thornton, Schad, Treibel, Weingärtner and Akçakaya.)
Databáze:	MEDLINE
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