The relationship between serum CTRP-5, C3a/desArg, and complement-C3 levels and hypothyroidism in women with polycystic ovary syndrome.

Autor: Abdul-Ameer F; Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, P.O. Box: 1449614525, Tehran, Iran.; College of Medicine, University of Karbala, Karbala, Iraq., AlAsadi IJA; College of Medicine, University of Karbala, Karbala, Iraq., Hosseini A; Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran., Bahreini E; Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, P.O. Box: 1449614525, Tehran, Iran. Bahreini.e@iums.ac.ir.
Jazyk: angličtina
Zdroj: BMC endocrine disorders [BMC Endocr Disord] 2024 Dec 18; Vol. 24 (1), pp. 272. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1186/s12902-024-01801-3
Abstrakt: Introduction: Many patients with polycystic ovary syndrome (PCOS) also experience thyroid disorders. There is a notable similarity in energy metabolism among PCOS, C1q/tumor necrosis factor (TNF)-related proteins (CTRP-5)deficiency, C3a/desArg (also known as acylation-stimulating protein (ASP)) deficiency, and hypothyroidism. This study aimed to investigate the relationship between serum levels of these factors and hypothyroidism in patients with PCOS. Improved clarity and vocabulary, corrected minor grammatical issues, and enhanced readability.
Methods: This case-control study involved three groups: healthy women (control group), women with PCOS and hypothyroidism, and women with PCOS without hypothyroidism. Serum levels of FBS, total cholesterol, triglycerides, and HDL-C were measured using enzymatic and colorimetric methods. TSH, T4, T3, and anti-thyroid peroxidase (Anti-TPO) levels were determined by ELISA to screen for hypothyroidism in women with PCOS. Additionally, serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), CTRP-5, ASP, and complement C3 were assessed using the ELISA method.
Results: The results indicated that reduced blood levels of CTRP-5, along with elevated levels of ASP (C3a/desArg) and complement C3 in patients with PCOS, may be linked to dysregulation of the thyroid gland. Furthermore, the study observed that changes in these parameters, in conjunction with thyroid dysfunction, are associated with pathological alterations in lipid profiles and blood glucose levels.
Conclusion: While changes in CTRP-5, ASP, and complement C3 can influence energy expenditure and storage in PCOS and thyroid function, the complex nature of PCOS requires further research to investigate the prevalence of hypothyroidism in individuals with PCOS.
Clinical Trial Number: Not applicable.
Competing Interests: Declarations. Ethics approval and consent to participate: All procedures conducted in the study involving human participants adhered to the ethical standards set forth by the institutional and/or national research committee and were aligned with the principles outlined in the 1964 Helsinki Declaration. The Ethics Commission at the Iran University of Medical Sciences assessed the project’s adherence to the “Helsinki Laws” and approved the study (Ethical Code: IR.IUMS.REC.1402.669). Upon selecting a suitable participant following a thorough examination by a physician, she was invited to participate in the project. The project’s objectives, procedures, including blood sampling, and the assurance of data confidentiality were explained to her, along with the option to withdraw from the study at any point of her choosing. Informed consent was obtained from all individual participants who were part of the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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