Effects of long-acting versus short-acting granulocyte colony stimulating factor after radiotherapy in gynecologic malignancies: a prospective observational cohort study.

Autor: Chen X; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Beijing, Dongcheng District, 100730, China., Wu M; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Beijing, Dongcheng District, 100730, China., Ma S; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Beijing, Dongcheng District, 100730, China., Tan X; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Beijing, Dongcheng District, 100730, China., Zhong S; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Beijing, Dongcheng District, 100730, China., Li L; Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Beijing, Dongcheng District, 100730, China. lileigh@163.com.
Jazyk: angličtina
Zdroj: BMC cancer [BMC Cancer] 2024 Dec 18; Vol. 24 (1), pp. 1512. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1186/s12885-024-13296-1
Abstrakt: Little is known about the role of the protective effects of granulocyte colony-stimulating factor (G-CSF) in patients after radiotherapy. The aim of the present study was to explore the prophylactic effects of long-acting granulocyte colony-stimulating factor (G-CSF) on febrile neutropenia (FN) and myelosuppression in chemotherapy patients with gynecologic malignancies after pelvic radiotherapy. Patients voluntarily participated in a study group (long-acting G-CSF for all chemotherapy cycles) and a control group (short-acting G-CSF) after they were educated about G-CSF utilization. The incidences of FN and myelosuppression, as well as adverse events, were compared between the two groups. A regression model was used to determine the risk factors for FN and myelosuppression. From January 6, 2019, to August 22, 2019, 61 patients were included in the final analysis, with 286 chemotherapy cycles. There were 14 (23.0%) and 57 (77.0%) patients in the study and control groups, respectively. The study group had significantly fewer complete blood count tests, fewer outpatient clinic visits, fewer short-acting G-CSF doses, and lower incidences of FN and myelosuppression per chemotherapy cycle. According to the binary regression model, the use of long-acting G-CSF was the only factor associated with a decreased incidence of myelosuppression but not FN. The major adverse event related to G-CSF was mild bone pain. In conclusion, long-acting G-CSF may effectively reduce the incidence of FN and myelosuppression with mild adverse effects during chemotherapy after radiotherapy.Trial registrationRegistered at https://www.clinicaltrials.gov/  on January 4, 2019 (NCT03793205).
Competing Interests: Declarations. Ethics approval and consent to participate: The Institutional Review Board of Peking Union Medical College Hospital approved this study (No. JS1723). The registration number is NCT03793205 (clinicaltrials.gov, registered on January 4, 2019). All patients provided informed consent before participation. Consent for publication: Not applicable. Competing interests: All the authors declare that they have no conflicts of interest to disclose.
(© 2024. The Author(s).)
Databáze: MEDLINE
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