The additive interaction of healthy lifestyles and genetic susceptibility on colorectal cancer risk in prediabetes: a large population-based prospective cohort study.

Autor: Wang W; School of Medicine, Nankai University, Tianjin, 300071, China.; Department of General Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China., Cheng Y; The First Clinical Institute, Zunyi Medical University, Zunyi, 563000, China., Meng Q; Department of General Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China., Jia B; School of Medicine, Nankai University, Tianjin, 300071, China. baoqingjia@126.com.; Department of General Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China. baoqingjia@126.com., Yao D; Department of Epidemiology and Biostatistics, School of Public Health, Xi'an, Jiaotong University Health Science Center, Xi'an, China. 18678800909@163.com., Cheng Y; Department of Endocrinology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, 250021, China. chengyiping93@163.com.
Jazyk: angličtina
Zdroj: BMC gastroenterology [BMC Gastroenterol] 2024 Dec 18; Vol. 24 (1), pp. 462. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1186/s12876-024-03552-w
Abstrakt: Objective: We aimed to investigate the interrelationships among polygenic risk scores (PRS), healthy lifestyle factors (HLFs), and colorectal cancer (CRC) risk in individuals with prediabetes. To investigate whether adherence to HLFs influence CRC risk in those with elevated PRS within this specific population.
Methods: Data from 22,408 prediabetes participants without CRC at baseline were analyzed from the UK Biobank. HLFs were graded using healthy lifestyle scores (HLSs) and classified as favorable, intermediate, or unfavorable, while the PRS for CRC was categorized as high, medium, or low. Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for CRC risk.
Results: High PRS (HR: 2.36; 95% CI: 1.86-3.00) and medium PRS (HR: 1.42; 95% CI: 1.09-1.83) prediabetes were associated with increased CRC risk compared to those with low PRS. HLFs were linked to lower CRC risk in a dose-response manner, with never smoking (HR: 0.69; 95% CI: 0.57-0.84) and maintaining a healthy BMI (HR: 0.64; 95% CI: 0.49-0.82) associated with reduced CRC risk. Adherence to favorable HLFs may reduce the CRC risk in those with medium (HR: 0.51; 95% CI: 0.27-0.95) and high PRS (HR: 0.62; 95% CI: 0.39-0.99) over 15 years of follow-up. In participants with high PRS and unfavorable HLFs, the excess risk due to the additive interaction between PRS and HLFs was 1.41% (p < 0.01), especially for women (1.07%).
Conclusions: There is an additive interaction of PRS and HLFs on CRC risk in individuals with prediabetes. Adopting favorable HLFs should be integrated into the management of prediabetes individuals to reduce the risk of CRC.
Competing Interests: Declarations. Ethics approval and consent to participate: All participants gave written informed consent. This study complied with the ethical standards of the Declaration of Helsinki and the protocol using secondary data received approval from the UKB data has approval from the North West Multi-centre Research Ethics Committee (MREC) (REC reference: 21/NW/0157). Consent for publication: Written informed consent for publication of the details in this manuscript, including any personal or clinical information, was obtained from all participants by UKB ( https://www.ukbiobank.ac.uk/ ). Competing Interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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