Ca V 3.2 T-type calcium channels contribute to CGRP- induced allodynia in a rodent model of experimental migraine.
Autor: | Baggio DF; Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, PR, Brazil., Gambeta E; Department of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Souza IA; Department of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Huang S; Department of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Zamponi GW; Department of Clinical Neuroscience, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Chichorro JG; Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, PR, Brazil. juliana.chichorro@ufpr.br. |
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Jazyk: | angličtina |
Zdroj: | The journal of headache and pain [J Headache Pain] 2024 Dec 18; Vol. 25 (1), pp. 219. Date of Electronic Publication: 2024 Dec 18. |
DOI: | 10.1186/s10194-024-01921-0 |
Abstrakt: | Background: Migraine is a painful neurological syndrome characterized by attacks of throbbing headache, of moderate to severe intensity, which is associated with photo- and phono- sensitivity as well as nausea and vomiting. It affects about 15% of the world's population being 2-3 times more prevalent in females. The calcitonin gene-related peptide (CGRP) is a key mediator in the pathophysiology of migraine, and a significant advance in the field has been the development of anti-CGRP therapies. The trigeminal ganglion (TG) is thought to be an important site of action for these drugs. Moreover, experimental migraine can be induced by CGRP injection in the TG. The signaling pathway induced by CGRP in the TG is not fully understood, but studies suggest that voltage-gated calcium channels contribute to CGRP effects relevant to migraine. Objective: We hypothesised that CGRP injection in the TG enhances Ca Results: A Co-Immunoprecipitation assay in tsA-201 cells revealed that Ca Conclusion: The present study suggests that CGRP modulates Ca Competing Interests: Declarations. Competing interests: The authors declare no competing interests. (© 2024. The Author(s).) |
Databáze: | MEDLINE |
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