Eco-friendly green synthesis of silver nanoparticles from guajava leaves extract for controlling organophosphorus pesticides hazards, characterization, and in-vivo toxicity assessment.

Autor: Albadawi EA; Department of Basic Medical Sciences, College of Medicine, Taibah University, Al-Madinah Al- Munawara, Saudi Arabia. ebadawi@taibahu.edu.sa., Musa ENA; Department of Basic Medical Sciences, College of Medicine, Taibah University, Al-Madinah Al- Munawara, Saudi Arabia.; Department of Anatomy and Embryology, Faculty of Medicine, Cairo University, Cairo, Egypt., Ghaban HM; Department of Basic Medical Sciences, College of Medicine, Taibah University, Al-Madinah Al- Munawara, Saudi Arabia., Ebrahim NA; Department of Basic Medical Sciences, College of Medicine, Taibah University, Al-Madinah Al- Munawara, Saudi Arabia.; Department of Human Anatomy and Embryology, Faculty of Medicine, Mansoura University, Mansoura, Egypt., Albadrani MS; Department of Family and Community Medicine and Medical Education, College of Medicine, Taibah University, Al-Madinah Al-Munawara, Saudi Arabia. mbadrani@taibahu.edu.sa., El-Tokhy AI; Plant Protection Department, Faculty of Agriculture, Beni-Suef University, Beni-Suef, Egypt.
Jazyk: angličtina
Zdroj: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2024 Dec 18; Vol. 25 (1), pp. 98. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1186/s40360-024-00826-7
Abstrakt: This study explores an eco-friendly approach to mitigate risks associated with organophosphorus insecticides, particularly Chlorpyrifos, by synthesizing silver nanoparticles (AgNPs) using Psidium guajava leaf extract and preparing a nanocomposite (AgNPs/S18) with Chlorpyrifos pesticide. The green-synthesized AgNPs and AgNPs/S18 nanocomposite were characterized using various analytical techniques, confirming the successful synthesis of AgNPs with an average size of 37 nm and forming a stable nanocomposite. Antibacterial assays demonstrated significant activity against Staphylococcus aureus, with AgNPs showing an 87.8% reduction and the nanocomposite achieving a 72% reduction in bacterial population. Cytotoxicity evaluations on normal liver and liver cancer cell lines revealed enhanced cytotoxicity of the nanocomposite compared to AgNPs alone, suggesting potential applications in targeted therapies. In vivo studies on rats revealed the protective effects of AgNPs and the nanocomposite against Chlorpyrifos-induced toxicity in liver and kidney tissues. Histopathological and ultrastructural analyses showed both treatments, particularly the nanocomposite, significantly mitigated cellular damage caused by Chlorpyrifos exposure. These findings suggest that green-synthesized AgNPs and their nanocomposite with Chlorpyrifos offer a promising approach to reducing pesticide hazards while maintaining efficacy. This research contributes to developing safer alternatives in pest management, addressing the need for more environmentally friendly agricultural practices while protecting human health and ecosystems.
Competing Interests: Declarations. Ethics approval and consent to participate: All study protocols were approved by the research ethics committee in the College of Pharmacy (COPTU-REC) at Taibah University. The ethical approval ID is COPTU-REC-92-20240320. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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