A rare case of FH-deficient renal cell carcinoma with signet ring cells features.

Autor: Lu Y; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of Pathology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Hu C; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China., Jia J; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of urology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Liu Y; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of Pathology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Wen Y; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of Pathology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Zhang H; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of Pathology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Wang X; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of Pathology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Li H; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of urology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Shen G; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.; Departments of Pathology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China., Huang W; Shenzhen Hospital, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China. huangwt@cicams.ac.cn.; Departments of Pathology, Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences, Shenzhen, China. huangwt@cicams.ac.cn.
Jazyk: angličtina
Zdroj: Diagnostic pathology [Diagn Pathol] 2024 Dec 18; Vol. 19 (1), pp. 159. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1186/s13000-024-01583-1
Abstrakt: Fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) is a clinically aggressive tumor with high rates of progression and mortality. A wide range of morphological variations has been observed in FH-deficient RCC, initially described as type 2 papillary RCC or unclassified RCC. Here, we report a case of FH-deficient RCC with rare signet ring cells features. The patient was diagnosed with FH-deficient renal cell carcinoma and suspected to have hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. After 4 months, pulmonary metastasis occurred in the patient. We herein describe the first case of FH-deficient renal tumor with signet ring cells features, which expands the morphological spectrum of this tumor. More importantly, this variant can be a diagnostic pitfall, we emphasize that pathologists should consider not only the diagnosis of metastatic signet ring cell carcinoma and ALK rearrangement renal cell carcinoma but also FH-deficient renal cell carcinoma.
Competing Interests: Declarations. Ethics statement: Written informed consent from the patients was not required to participate in this study in accordance with the national legislation and the institutional requirements. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article. Conflict of interest: All authors have no conflicts of interest to declare in relation to this article. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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