Regulation of intestinal tissue‑resident memory T cells: a potential target for inflammatory bowel disease.

Autor: Xia X; Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China.; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China., Huang Z; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China., Xu C; Department of Nuclear Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China., Fu H; Center for Clinical Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, China., Wang S; Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China., Tian J; Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China. tianjie@ujs.edu.cn.; Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China. tianjie@ujs.edu.cn., Rui K; Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China. ruike@ujs.edu.cn.
Jazyk: angličtina
Zdroj: Cell communication and signaling : CCS [Cell Commun Signal] 2024 Dec 18; Vol. 22 (1), pp. 610. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1186/s12964-024-01984-1
Abstrakt: Tissue-resident memory T (TRM) cells are populations which settle down in non-lymphoid tissues instead of returning to secondary lymph organs after the antigen presentation. These cells can provide rapid on-site immune protection as well as long-term tissue damage. It is reported that TRM cells from small intestine and colon exhibited distinctive patterns of cytokine and granzyme expression along with substantial transcriptional and functional heterogeneity. In this review, we focus on the reason why they lodge in intestinal tract, their developmental plasticity of going back to to circulation, as well as their regulators associated with retention, maintenance, exhaustion and metabolism. We also elaborate their role in the inflammatory bowel disease (IBD) and discuss the potential therapeutic strategies targeting TRM cells.
Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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