Apoptotic body based biomimetic hybrid nanovesicles to attenuate cytokine storms for sepsis treatment.

Autor: Lan H; Department of Pharmacy, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, 541002, China.; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Zhou Z; Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Hu Q; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Xie Q; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Li X; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Tian T; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Wang Y; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Yang C; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Kong L; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China., Fu D; Department of Orthopaedics, Shanghai Jiaotong University Affiliated Shanghai Sixth People's Hospital, Shanghai, 200025, China. fudehao@sjtu.edu.cn., Guo Y; Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. yuanyuanguo@hust.edu.cn.; Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, Huazhong University of Science and Technology, Wuhan, 430077, China. yuanyuanguo@hust.edu.cn., Zhang Z; Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, 430030, China. zhipingzhang@mail.hust.edu.cn.; National Engineering Research Center for Nanomedicine, Huazhong University of Science and Technology, Wuhan, 430030, China. zhipingzhang@mail.hust.edu.cn.
Jazyk: angličtina
Zdroj: Journal of nanobiotechnology [J Nanobiotechnology] 2024 Dec 19; Vol. 22 (1), pp. 775. Date of Electronic Publication: 2024 Dec 19.
DOI: 10.1186/s12951-024-03058-3
Abstrakt: Sepsis is a severe immune response to pathogens that is associated with high mortality rate and a paucity of efficacious treatment options. It is characterized by the hyperactivation of macrophages and the occurrence of cytokine storms. Given the anti-inflammatory properties of M2 macrophages and their derived apoptotic bodies (AB), as well as the specific uptake of these by macrophages, a novel approach was employed to combine AB with artificial liposomes to create apoptotic body based biomimetic hybrid nanovesicles (L-AB). The L-AB effectively inherited "eat me" signaling molecules on the surface of the AB, thereby facilitating their targeted uptake by macrophages in both in vitro and in vivo settings. The administration of L-AB for the delivery of dexamethasone effectively augmented the therapeutic efficacy of the drug, mitigated macrophage hyperactivation and tissue damage in vivo, and consequently enhanced the survival rate of septic mice. Taken together, these findings suggest that the apoptotic body biomimetic nanovesicles may represent a potential drug delivery system capable of specifically targeting macrophages for the treatment of sepsis.
Competing Interests: Declarations. Ethics approval and consent to participate: All the animal experiments were approved by the Experimental Animal Center of HUST. Animal experiments were carried out in compliance with the Guide for the Animals Care and Ethics Committee of HUST, with the assigned [2023] IACUC number (3678). Consent for publication: All authors consent for publication. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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