Pediatric SARS-CoV-2 long term outcomes study (PECOS): cross sectional analysis at baseline.

Autor:	Montealegre Sanchez GA; Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. montealegrega@nih.gov., Arrigoni LE; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA., Yonts AB; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Center for Translational Research, Children's National Research Institute, Washington, DC, USA.; Division of Pediatric Infectious Diseases, Children's National Hospital, Washington, DC, USA., Rubenstein KB; Clinical Monitoring Research Program Directorate (CMRPD), National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Bost JE; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Center for Translational Research, Children's National Research Institute, Washington, DC, USA.; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC, USA., Wolff MT; Clinical Research Directorate (CRD), National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Barrix MC; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Bandettini WP; National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Boateng B; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Bulas DI; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA., Burklow TR; Office of Clinical Research Training and Medical Education, Clinical Center (CC), NIH, Bethesda, MD, USA., Carlyle KP; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Chen M; National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Das S; Department of Laboratory Medicine (DLM), CC, NIH, Bethesda, MD, USA., Dewar RL; Division of Clinical Research (DCR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA., Dixon AA; Department of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA., Edu MA; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Falik RL; Division of Pediatric Infectious Diseases, Children's National Hospital, Washington, DC, USA., Geslak ML; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Gierdalski M; Center for Translational Research, Children's National Research Institute, Washington, DC, USA.; Division of Biostatistics and Study Methodology, Children's National Research Institute, Washington, DC, USA., Harahsheh AS; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Division of Cardiology, Children's National Hospital, Washington, DC, USA., Herbert LJ; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Division of Psychology & Behavioral Health, Children's National Hospital, Washington, DC, USA., Highbarger J; Division of Intramural Research (DIR), NIAID, NIH, Bethesda, MD, USA., Huq SR; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Ko A; Center for Genetic Medicine Research, Children's National Research Institute, Washington, DC, USA., Koumbourlis AC; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Division of Pulmonary & Sleep Medicine, Children's National Hospital, Washington, DC, USA., Lacey SR; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Division of Cardiology, Children's National Hospital, Washington, DC, USA., Lipton AJ; National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Monaghan M; Division of Psychology & Behavioral Health, Children's National Hospital, Washington, DC, USA., Ndour AS; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Olivieri LJ; UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA., Pillai DK; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Division of Pulmonary & Sleep Medicine, Children's National Hospital, Washington, DC, USA., Rehm CA; Division of Intramural Research (DIR), NIAID, NIH, Bethesda, MD, USA., Sable CA; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Division of Cardiology, Children's National Hospital, Washington, DC, USA., Sachdev V; National Heart, Lung, and Blood Institute (NHLBI), NIH, Bethesda, MD, USA., Thurm AE; National Institute of Mental Health (NIMH), NIH, Bethesda, MD, USA., Truong UT; Division of Cardiology, Children's National Hospital, Washington, DC, USA., Turkbey EB; Department of Radiology and Imaging Sciences, CC, NIH, Bethesda, MD, USA., Vilain E; Institute for Clinical and Translational Science, University of California Irvine, Irvine, CA, USA., Weyers S; Clinical Monitoring Research Program Directorate (CMRPD), National Cancer Institute Frederick National Laboratory for Cancer Research, Frederick, MD, USA., White JS; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Williams AA; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA., Zember J; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Department of Diagnostic Imaging and Radiology, Children's National Hospital, Washington, DC, USA., Liang CJ; Biostatistics Research Branch, NIAID, NIH, Bethesda, MD, USA., Delaney M; Center for Cancer and Immunology Research (CCIR), Children's National Research Institute, Washington, DC, USA.; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Department of Pathology and Laboratory Medicine, Children's National Hospital, Washington, DC, USA.; Department of Pathology, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA., Batshaw ML; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Clinical Research Institute, Children's National Hospital, Washington, DC, USA., Notarangelo LD; Laboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH, Bethesda, MD, USA., Wessel DL; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Department of Critical Care Medicine, Children's National Hospital, Washington, DC, USA., Barron K; Division of Intramural Research (DIR), NIAID, NIH, Bethesda, MD, USA.; Laboratory of Clinical Immunology and Microbiology (LCIM), NIAID, NIH, Bethesda, MD, USA., DeBiasi RL; Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.; Center for Translational Research, Children's National Research Institute, Washington, DC, USA.; Division of Pediatric Infectious Diseases, Children's National Hospital, Washington, DC, USA.; Department of Microbiology, Immunology and Tropical Medicine, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA.
Jazyk:	angličtina
Zdroj:	Pediatric research [Pediatr Res] 2024 Dec 18. Date of Electronic Publication: 2024 Dec 18.
DOI:	10.1038/s41390-024-03777-1
Abstrakt:	Background: PECOS is an ongoing study aimed to characterize long-term outcomes following pediatric SARS-CoV-2 infection. Methods: This is a cross-sectional analysis of infected and uninfected cohorts at baseline. Participants (0-21 years) with laboratory-confirmed SARS-CoV-2 infection were enrolled as infected. Uninfected were defined as individuals without history or laboratory evidence of SARS-CoV-2 infection. Outcome measures included demographics, medical history, review of symptoms, physical exam, cardiopulmonary evaluation and validated psychological and developmental surveys. Primary outcomes were cohort comparisons for abnormalities on all measures. Results: 654 participants (541 infected, 113 uninfected) completed baseline visits by June 30, 2023. Infected participants were more likely to report constitutional (OR: 2.24), HEENT (OR: 3.74); respiratory (OR: 2.41), or gastrointestinal (OR: 2.58) symptoms. Infected had worse scores in domains of Pain, Fatigue, Global Health, Physical and Cognitive functioning, Mobility and Sleep disturbances when compared to uninfected controls using Patient Reported Outcomes. Cardiopulmonary findings were similar among cohorts. Conclusions: The first report of this ongoing longitudinal study demonstrates that infected participants were more likely to report symptoms compared to uninfected controls, which may affect performance and quality of life of these individuals. Longitudinal data will increase understanding of long-term effects of SARS-CoV-2 infection in children. Clinicaltrials: gov Identifier: NCT04830852 IMPACT: This study establishes a large, diverse, prospective, longitudinal, multi-center cohort of children with history of SARS-CoV-2 infection compared to an uninfected cohort to be followed for 3 years. Cross-sectional cohort analysis at study entry showed infected participants were more likely to report constitutional, respiratory, and GI symptoms compared to uninfected controls. Infected participants were more likely to have significantly worse parent-reported performance in 6 of 10 Patient Reported Outcome Measures domains. Continued study of this cohort will help identify clinical sequelae of COVID-19, characterize the immune response to SARS-CoV-2 infection, and identify potential genetic/immunologic factors associated with long-term outcomes. Competing Interests: Competing interests: The authors declare no competing interests. Informed consent: Written Informed Consent was obtained from all participants ≥18 years of age and at least one parent or legal guardian per participant <18 years of age. Written Assent was obtained for all participants 12–17 years of age. (© 2024. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze:	MEDLINE
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