Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases.

Autor: Seremet T; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Di Domizio J; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Girardin A; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Yatim A; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Jenelten R; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Messina F; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Saidoune F; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Schlapbach C; Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland., Bogiatzi S; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Minisini F; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Garzorz-Stark N; Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg, Germany., Leuenberger M; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Wüthrich H; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Vernez M; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Hohl D; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Eyerich S; Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg, Germany., Eyerich K; Department of Dermatology and Venereology, Medical Center, University of Freiburg, Freiburg, Germany., Guenova E; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Paul C; Department of Dermatology and Venereology, CHU Toulouse, Toulouse, France., Gottardo R; Biomedical Data Science Center, CHUV, UNIL, and SIB, Lausanne, Switzerland., Conrad C; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland., Gilliet M; Department of Dermatology, Lausanne University Hospital CHUV and University of Lausanne, 1011, Lausanne, Switzerland. michel.gilliet@chuv.ch.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Dec 18; Vol. 15 (1), pp. 10688. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1038/s41467-024-54559-6
Abstrakt: Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways. Seven modules are identified, representing key immune pathways: Th17, Th2, Th1, Type I IFNs, neutrophilic, macrophagic, and eosinophilic. These modules allow the development of a molecular map with high diagnostic efficacy for inflammatory skin diseases and clinico-pathologically undetermined cases. Aligning dominant modules with treatment targets offers a rational framework for treatment selection, improving response rates in both treatment-naïve patients and non-responders to targeted therapies. Overall, our approach offers precision medicine for inflammatory skin diseases, utilizing transcriptional modules to support diagnosis and guide personalized treatment selection.
Competing Interests: Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: