Prediagnostic Phase of Progressive Supranuclear Palsy in a Longitudinal Epidemiological Study of Dementia and Aging: A Case Report.

Autor:	Ishii K; Department of Neurology, North Medical Center, Kyoto Prefectural University of Medicine, Japan., Takahashi H; Department of Neurology, North Medical Center, Kyoto Prefectural University of Medicine, Japan., Kubota-Hanya M; Department of Neurology, North Medical Center, Kyoto Prefectural University of Medicine, Japan., Yasuda R; Department of Neurology, Kyoto Prefectural University of Medicine, Japan., Niwa F; Department of General Medicine and Community Healthcare, Kyoto Prefectural University of Medicine, Japan., Kondo M; Department of Neurology, Kyoto Prefectural University of Medicine, Japan.; Kyoto Prefecture Rehabilitation Support Center, Japan., Mizuno T; Department of Neurology, Kyoto Prefectural University of Medicine, Japan.
Jazyk:	angličtina
Zdroj:	Internal medicine (Tokyo, Japan) [Intern Med] 2024 Dec 19. Date of Electronic Publication: 2024 Dec 19.
DOI:	10.2169/internalmedicine.4529-24
Abstrakt:	A 63-year-old previously healthy man participated in a longitudinal epidemiologic study of dementia and aging. Although he initially showed no subjective symptoms and a normal motor function, verbal fluency test scores gradually declined, and progressive atrophy of the frontal lobes was observed on magnetic resonance imaging of the head. At 71 years old, progressive supranuclear palsy (PSP) was diagnosed after supranuclear gaze palsy, and gait disturbance developed. This longitudinal epidemiological study suggests that verbal symptoms and mild frontal lobe atrophy may be evident in the premotor phase of PSP.
Databáze:	MEDLINE
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