Professionally and non-professionally applied household insecticides during pregnancy and early life and their associations with autism spectrum disorder and developmental delay in the CHARGE case-control study.

Autor: Goodrich AJ; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA. Electronic address: ajgoodrich@ucdavis.edu., Tancredi DJ; Department of Pediatrics, University of California Davis, Sacramento, CA, USA., Ludeña YJ; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA., Bennett DH; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA., Hertz-Picciotto I; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA., Schmidt RJ; Department of Public Health Sciences, School of Medicine, University of California Davis, Sacramento, CA, USA; Medical Investigation of Neurodevelopmental Disorders (MIND) Institute, University of California Davis, Sacramento, CA, USA.
Jazyk: angličtina
Zdroj: Environmental research [Environ Res] 2024 Dec 18; Vol. 267, pp. 120651. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1016/j.envres.2024.120651
Abstrakt: Background: Autism Spectrum Disorder (ASD) is an increasing concern globally, with risks attributed to both genetic and environmental factors, including pesticide exposures. The CHARGE case-control study collected data to examine the relationship between household insecticide use and ASD or developmental delay (DD).
Methods: Participants (n = 1526) aged 2-5 years from the CHARGE study encompassed children with clinically confirmed ASD (n = 810), DD (n = 186), and typically developing controls (n = 530) frequency matched to ASD children by age, sex, and geographic region. Household insecticide use was determined from parent interviews, as were the timing, frequency, and type of applications (professionally or non-professionally applied; indoor, outdoor, and flea applications) from three months pre-conception to the child's second birthday. Logistic regression models were adjusted for confounders to estimate odds ratios (OR) for ASD or DD associated with insecticide exposure.
Results: Professionally applied indoor insecticides were associated with greater than two-fold increased odds of ASD for all time periods (OR: pre-pregnancy, 2.62 (1.26, 5.44); pregnancy, 2.52 (1.41, 4.48); year 1, 2.20 (1.33, 3.64); year 2, 2.13 (1.29, 3.49)). Odds were also elevated for any outdoor application during years 1 and 2 (OR: 1.37 (1.05, 1.79) and 1.34 (1.03, 1.74), respectively), however, significance did not hold after false discovery rate correction. Higher exposure frequency was associated with greater odds of ASD for nearly all application types and time periods. Non-professional indoor insecticide use was associated with increased odds of DD in trimester 3 and the pregnancy period (OR: 1.72 (1.03, 2.89) and 1.58 (1.03, 2.40), respectively).
Conclusion: Professionally applied indoor insecticides were consistently associated with ASD. The strong trend of increased odds with more frequent exposures, additional evidence for DD, and widespread use of household insecticides support increased regulatory scrutiny and public health interventions to minimize exposure during critical developmental windows.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Daniel Tancredi reports a relationship with International Flavors & Fragrances Inc that includes: consulting or advisory. Daniel Tancredi reports a relationship with Synbiotic Health that includes: consulting or advisory. Rebecca J Schmidt reports a relationship with Beasley Allen Law Firm that includes: consulting or advisory. Rebecca J Schmidt reports a relationship with MotherToBaby - The Organization of Teratology Information Specialists (OTIS) that includes: travel reimbursement. Rebecca J Schmidt reports a relationship with Simons Foundation Autism Research Initiative that includes: funding grants. Rebecca J Schmidt reports a relationship with St. Johns - Centre for Advanced Research and Excellence in Autism and Developmental Disorders that includes: travel reimbursement. Rebecca J Schmidt reports a relationship with National Institutes of Health that includes: travel reimbursement.
(Copyright © 2024. Published by Elsevier Inc.)
Databáze: MEDLINE
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