Association between Mediterranean diet adherence and Parkinson's disease: a systematic review and meta-analysis.

Autor:	Zhao J; College of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Avenue West, Chengdu, Sichuan Province, China., Peng Y; Guangzhou First People's Hospital, Second Affiliated Hospital of South China University of Technology, No. 1 Panfu Road, Guangzhou, Guangdong Province, China., Lin Z; Affiliated Sichuan Provincial Rehabilitation Hospital of the Chengdu University of Traditional Chinese Medicine, No. 81, Bayi Road, Yongning Street, Chengdu, Sichuan Province, China., Gong Y; Affiliated Sichuan Provincial Rehabilitation Hospital of the Chengdu University of Traditional Chinese Medicine, No. 81, Bayi Road, Yongning Street, Chengdu, Sichuan Province, China. Electronic address: Gongyulai990609@163.com.
Jazyk:	angličtina
Zdroj:	The journal of nutrition, health & aging [J Nutr Health Aging] 2024 Dec 17; Vol. 29 (2), pp. 100451. Date of Electronic Publication: 2024 Dec 17.
DOI:	10.1016/j.jnha.2024.100451
Abstrakt:	Background and Aims: Parkinson's disease (PD) is a chronic neurodegenerative disorder, and past research suggests that adherence to the Mediterranean diet (MD) may influence the risk of PD. However, there are varying conclusions among different studies regarding the correlation between long-term adherence to the MD and the occurrence of PD. This meta-analysis aimed to investigate the association between MD adherence and PD incidence. Methods: This meta-analysis was registered on PROSPERO (CRD42024520410). We searched PubMed, Embase, Web of Science, and Cochrane databases to identify observational studies, including prospective cohorts, case-control, and cross-sectional studies, up to February 2024. Studies reported on MD adherence were included, with MD adherence categorized through a quantifying score or index. The pool odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for the highest versus the lowest categories of MD score in relation to PD risk, using random-effects models. Additionally, bias assessment, heterogeneity assessment, sensitivity analysis, and subgroup analysis were performed. A total of 12 studies were included in the meta-analysis. Results: The overall effect size of PD risk was as follows: compared to the lowest adherence to the MD, the highest adherence to MD showed a significant negative correlation with the incidence of PD, with an overall OR of 0.75 (95% CI: 0.66, 0.84). Specifically, in studies diagnosing PD, the overall OR was 0.83 (95% CI: 0.74, 0.94), while in studies diagnosing prodromal Parkinson's disease (pPD), the overall OR was 0.67 (95%CI: 0.59, 0.76). For individuals aged <60 years, the overall OR was 0.70 (95%CI: 0.62, 0.78), whereas, for those aged ≥60 years, the overall OR was 0.86 (95%CI: 0.74, 0.99). Conclusions: The evidence from this meta-analysis demonstrates a significant negative correlation between adherence to MD patterns and the risk of PD, suggesting that the MD may serve as a protective factor for PD. This dietary pattern may be particularly beneficial in reducing the risk of pPD. Competing Interests: Declaration of competing interest The authors declare no conflict of interest. All authors have read and approved this version of the article, and due care has been taken to ensure the integrity of the work. Neither the entire paper nor any part of its content has been published or accepted elsewhere. It is not being submitted to any other journal. (Copyright © 2024. Published by Elsevier Masson SAS.)
Databáze:	MEDLINE
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