The three-dimensional genome drives the evolution of asymmetric gene duplicates via enhancer capture-divergence.

Autor: Lee U; Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA.; Laboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA., Arsala D; Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA., Xia S; Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA., Li C; Laboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA., Ali M; Department of Neuroscience and Developmental Biology, University of Vienna, Vienna, Austria., Svetec N; Laboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA., Langer CB; Laboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA., Sobreira DR; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Eres I; Department of Human Genetics, University of Chicago, Chicago, IL, USA., Sosa D; Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA., Chen J; Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA., Zhang L; Chinese Institute for Brain Research, Beijing, China., Reilly P; Department of Anthropology, Yale University, New Haven, CT, USA., Guzzetta A; Department of Pathology, University of Chicago, Chicago, IL, USA., Emerson JJ; Department of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, USA., Andolfatto P; Department of Biological Sciences, Columbia University, New York, NY, USA., Zhou Q; Department of Neuroscience and Developmental Biology, University of Vienna, Vienna, Austria.; MOE Laboratory of Biosystems Homeostasis and Protection Life Sciences Institute, Zhejiang University, Hangzhou, Zhejiang, China., Zhao L; Laboratory of Evolutionary Genetics and Genomics, Rockefeller University, New York, NY, USA., Long M; Department of Ecology and Evolution, University of Chicago, Chicago, IL, USA.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2024 Dec 20; Vol. 10 (51), pp. eadn6625. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1126/sciadv.adn6625
Abstrakt: Previous evolutionary models of duplicate gene evolution have overlooked the pivotal role of genome architecture. Here, we show that proximity-based regulatory recruitment by distally duplicated genes is an efficient mechanism for modulating tissue-specific production of preexisting proteins. By leveraging genomic asymmetries, we performed a coexpression analysis on Drosophila melanogaster tissue data to show the generality of enhancer capture-divergence (ECD) as a significant evolutionary driver of asymmetric, distally duplicated genes. We use the recently evolved gene HP6 / Umbrea as an example of the ECD process. By assaying genome-wide chromosomal conformations in multiple Drosophila species, we show that HP6/Umbrea was inserted near a preexisting, long-distance three-dimensional genomic interaction. We then use this data to identify a newly found enhancer ( FLEE1 ), buried within the coding region of the highly conserved, essential gene MFS18 , that likely neofunctionalized HP6/Umbrea . Last, we demonstrate ancestral transcriptional coregulation of HP6/Umbrea 's future insertion site, illustrating how enhancer capture provides a highly evolvable, one-step solution to Ohno's dilemma.
Databáze: MEDLINE