Strategies to improve research participation by older people with cognitive impairment: a systematic review.

Autor:	Swan L; School of Medicine and Nursing Sydney, University of Notre Dame Australia, Darlinghurst, NSW, Australia.; Southern Adelaide Palliative Service, Flinders Medical Centre, Adelaide, SA, Australia., Kochovska S; St Vincent's Health Network Sydney, Cunningham Centre for Palliative Care, Darlinghurst, NSW, Australia.; Faculty of Health, IMPACCT, University of Technology Sydney, Ultimo, NSW, Australia., Ries N; Faculty of Law, University of Technology Sydney, Ultimo, NSW, Australia., Gilmore I; Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia., Parker D; Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW, Australia., Sinclair C; School of Psychology, University of New South Wales, Kensington, NSW, Australia., Sheehan C; Faculty of Health, IMPACCT, University of Technology Sydney, Ultimo, NSW, Australia.; Palliative Care Department, Calvary Health Care Kogarah, Kogarah, NSW, Australia., Collier A; Research Centre for Palliative Care Death and Dying, Flinders University, Adelaide, SA, Australia.; Prince of Wales Clinical School, University of New South Wales, Randwick, NSW, Australia., Lobb E; Faculty of Health, IMPACCT, University of Technology Sydney, Ultimo, NSW, Australia.; Palliative Care Department, Calvary Health Care Kogarah, Kogarah, NSW, Australia., Sheahan L; Clinical Ethics Service, South Eastern Sydney Local Health District, Randwick, NSW, Australia.; Sydney Health Ethics, University of Sydney, Camperdown, NSW, Australia., Brown L; Faculty of Health, IMPACCT, University of Technology Sydney, Ultimo, NSW, Australia., Chapman M; Southern Adelaide Palliative Service, Flinders Medical Centre, Adelaide, SA, Australia., Lee W; St Vincent's Health Network Sydney, Cunningham Centre for Palliative Care, Darlinghurst, NSW, Australia.; Faculty of Health, IMPACCT, University of Technology Sydney, Ultimo, NSW, Australia., Amgarth-Duff I; Faculty of Health, IMPACCT, University of Technology Sydney, Ultimo, NSW, Australia., To T; St Vincent's Health Network Sydney, Darlinghurst, NSW, Australia., Agar MR; Faculty of Health, IMPACCT, University of Technology Sydney, Ultimo, NSW, Australia.; School of Medicine, Australian National University, ACT, Australia., Hosie A; School of Medicine and Nursing Sydney, University of Notre Dame Australia, Darlinghurst, NSW, Australia.; St Vincent's Health Network Sydney, Cunningham Centre for Palliative Care, Darlinghurst, NSW, Australia.
Jazyk:	angličtina
Zdroj:	The Gerontologist [Gerontologist] 2024 Dec 18. Date of Electronic Publication: 2024 Dec 18.
DOI:	10.1093/geront/gnae188
Abstrakt:	Background and Objectives: Older people with cognitive impairment are unrepresented in clinical research. Our objective was to review evidence for strategies to support their research inclusion and participation. Research Design and Methods: Systematic review of published reports of inclusion and participation strategies for older people with cognitive impairment in clinical research (PROSPERO CRD42020212092). Five databases were searched September 2020, March 2023 and April 2024. Screening, full text review and data extraction were independently performed. Risk of bias was assessed using Scottish Intercollegiate Guidelines Network Methodology Checklists. Outcomes were participant characteristics, recruitment and consent processes, retention, experience, involvement of others, adverse events, and other reported outcomes. Results: Of 4564 identified sources, 12 studies were included. Nine compared recruitment strategies; three examined consent processes. Of 4,208 participants (mean age 78.3 years), 61% were female. Median (interquartile range) monthly recruitment rate was 10.3 (5.6-14.8). Participants had mild cognitive impairment, dementia and/or delirium and two-thirds of studies involved proxies or study partners. Community outreach or population screening had higher recruitment compared to primary care referral and/or screening. Formal capacity and consent methods achieved lower rates of consent compared to informal. A memory and organisational aid increased participants' ability to provide informed consent compared to standard assessment. Few studies reported participants' or recruiters' subjective experience, and no studies reported participant retention or adverse events. Discussion and Implications: Targeted, tailored and multi-pronged recruitment and consent strategies to support inclusion of older people with cognitive impairment appear promising. Higher quality studies are needed to confirm this finding. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Gerontological Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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