Human papillomavirus DNA detection in cervical samples from women of reproductive age in Mogadishu, Somalia.

Autor:	Garba B; Department of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Sh Nur MA; Department of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, Somalia., Adawe M; Department of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, Somalia., Adam MH; Department of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Mohamoud JH; Department of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Dahie HA; Department of Nursing and Midwifery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Ahmed MM; Department of Medicine and Surgery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Mohamud AK; Department of Public Health, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Mohamed SA; Department of Obstetrics and Gynecology, Dr. Sumait Hospital, SIMAD University, Mogadishu, Somalia., Orey FA; Department of Pediatrics and Child Health, Dr Sumait Hospital, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Hassan J; Department of Medicine and Surgery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Asowe HA; Department of Nursing and Midwifery, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia., Dirie NI; Department of Urology, Faculty of Medicine, and Health Sciences, SIMAD University, Mogadishu, Somalia.
Jazyk:	angličtina
Zdroj:	Journal of infection in developing countries [J Infect Dev Ctries] 2024 Nov 30; Vol. 18 (11), pp. 1746-1755. Date of Electronic Publication: 2024 Nov 30.
DOI:	10.3855/jidc.19982
Abstrakt:	Introduction: Somalia is among the countries with a high burden of human papillomavirus (HPV) infection in Sub-Saharan Africa. In 2022, 660,000 infections are reported among women globally, out of which 350,000 died from the disease. Most of the studies on HPV reported from Somalia are based on cytologic analysis which is a subjective and suboptimal assessment. The recent World Health Organization (WHO) guidelines for HPV recommend DNA-based testing as a better alternative to the traditional pap smear test. Methodology: This study was undertaken to determine the prevalence of HPV based on the preferred HPV DNA assay on cervical samples of women of reproductive age in Mogadishu, Somalia. The HPV DNA detection was carried out using real-time quantitative polymerase chain reaction (RT-PCR) assays to identify high-risk oncogenic HPV16, HPV18, and other high-risk HPV types. Results: Overall, 31.7% (60/189) of cervical samples were positive for HPV DNA. Out of this, 19.6% were high risk-HPV (hrHPV), 13.8% were HPV16, and 5.3% were HPV18. Moreover, age, income and education level were found to be significant risk factors for HPV infection. Conclusions: These results provide further proof that HPV continues to be a serious public health challenge in Somalia with the risk of progressing to fatal cervical cancer. Competing Interests: No Conflict of Interest is declared (Copyright (c) 2024 Bashiru Garba, Maryan A Sh Nur, Maryam Adawe, Mohamed H Adam, Jamal H Mohamoud, Hassan A Dahie, Mohamed M Ahmed, Abdirahman K Mohamud, Sadio A Mohamed, Fartun AH Orey, Jihaan Hassan, Hodo A Asowe, Najib I Dirie.)
Databáze:	MEDLINE
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