Convenient lanthanum-mediated synthesis of bulky tert -alkyl amines from nitriles.
| Autor: | Burke EK; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada. aspeed@dal.ca., Robertson KN; Department of Chemistry, Saint Mary's University, Halifax, Nova Scotia, B3H 3C3, Canada., Speed AWH; Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, B3H 4R2, Canada. aspeed@dal.ca. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Dec 18. Date of Electronic Publication: 2024 Dec 18. |
| DOI: | 10.1039/d4cc05831c |
| Abstrakt: | Tert -alkyl amines can be conveniently prepared in one step from nitriles by a double addition of ethyl or propyl Grignard reagent mediated by a commercially available lanthanum chloride-lithium chloride complex solution. The reaction operates on a variety of benzonitriles, with several heterocyclic nitriles and an alkyl nitrile also being suitable substrates. |
| Databáze: | MEDLINE |
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