Neonatal gut microbiota and risk of developing food sensitization and allergy.

Autor: Shibata R; Laboratorie for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Department of Pediatric Surgery, Graduate School of Medicine, Chiba University, Chiba City, Japan. Electronic address: ryohei.shibata@a.riken.jp., Nakanishi Y; Laboratorie for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan., Suda W; Laboratorie for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Nakano T; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba City, Japan., Sato N; Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba City, Japan., Inaba Y; Clinical Research Center, Chiba University Hospital, Chiba City, Japan., Kawasaki Y; Faculty of Nursing, Japanese Red Cross College of Nursing, Tokyo, Japan., Hattori M; Laboratorie for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Shimojo N; Center for Preventive Medical Sciences, Chiba University, Chiba City, Japan., Ohno H; Laboratorie for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Laboratorie for Microbiome Sciences, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Intestinal Microbiota Project, Kanagawa Institute of Industrial Science and Technology, Kawasaki, Japan. Electronic address: hiroshi.ohno@riken.jp.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Dec 09. Date of Electronic Publication: 2024 Dec 09.
DOI: 10.1016/j.jaci.2024.10.029
Abstrakt: Background: Food sensitization (FS) develops in early infancy and is a risk factor for subsequent food allergy (FA). Recent evidence suggests relationships of gut microbiota with FS and FA. However, little is known about the role of neonatal gut microbiota in the pathobiology of these manifestations.
Objectives: We sought to characterize gut microbiota in children using an enterotyping approach and determine the association of gut microbiota and the enterotypes with the development of FS and FA.
Methods: We combined gut microbiome and fecal short-chain fatty acid data from 2 longitudinal birth-cohort studies in Japan, clustered the microbiome data from children who were 1 week to 7 years old and their mothers and identified enterotypes. We also determined the associations of gut microbiota and enterotypes with risks of developing FS and FA across the 2 studies using multivariable regression models.
Results: Data from the 2563 microbiomes identified 6 enterotypes. More gut bacteria (eg, Bifidobacterium) in 1-month-old children showed significant relationships with the development of FS and FA than in 1-week-old children. Enterotypes at 1 month old consisted of Bacteroides-dominant, Klebsiella-dominant, and Bifidobacterium-dominant enterotypes. Bifidobacterium-dominant enterotypes with the highest fecal propionate concentration had the lowest risks of developing FS and FA, especially of hen egg white sensitization. Bifidobacterium-dominant enterotypes had lower risks at 2 years old in one study (vs Bacteroides-dominant enterotype, adjusted odds ratio [adjOR]: 0.10, 95% CI: 0.01-0.78; vs Klebsiella-dominant enterotype, adjOR: 0.10, 95% CI: 0.01-0.77) and at 9 months old in the other study (vs Bacteroides-dominant enterotype, adjOR: 0.33, 95% CI: 0.11-0.91).
Conclusions: In these birth-cohort studies, gut microbiome clustering identified distinct neonatal enterotypes with differential risks of developing FS and FA.
Competing Interests: Disclosure statement This study was supported by AMED-CREST JP19gm0710009 to H. Ohno from the Japan Agency for Medical Research and Development (Tokyo, Japan), Grants-in-Aid for Scientific Research (A) 22H00452 to H. Ohno from the Japan Society for the Promotion of Science (Tokyo, Japan), Japan Agency for Medical Research and Development (AMED) Moonshot Research & Development Program (JP22zf0127007 to H. Ohno), and RIKEN Interdisciplinary Research Program “Integrated Symbiology” and RIKEN Pioneering Project “Biology of Symbiosis” to H. Ohno from RIKEN (Saitama, Japan). The funding organizations were not involved in the collection, management, or analysis of the data; preparation or approval of the manuscript; or decision to submit the manuscript for publication. Disclosure of potential conflict of interest : T. Nakano receives honoraria for lecture from Sanofi Co, Ltd, Torii Pharmaceutical Co, Ltd, Maruho Co, Ltd, and joint research funds from Mitsubishi Gas Chemical Company, Inc, and Wako Filter Technology Co, Ltd. N. Shimojo receives honoraria and joint research fund for lecture from Natural Science, Ltd. The rest of the authors declare that they have no relevant conflicts of interest.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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