Multiparametric MRI targeted prostate biopsy: When omit systematic biopsy?
| Autor: | Pepe P; Urology Unit, Cannizzaro Hospital, Catania. piepepe@hotmail.com., Pepe L; Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina. ludopepe97@gmail.com., Fiorentino V; Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina. vincenzo.fiorentino@unime.it., Curduman M; Pathology Unit, Cannizzaro Hospital, Catania. mara.curduman@aoec.it., Fraggetta F; Pathology Unit, ASP Catania, 'Gravina' Hospital, Caltagirone. filippofra@hotmail.com. |
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| Jazyk: | angličtina |
| Zdroj: | Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica [Arch Ital Urol Androl] 2024 Nov 11; Vol. 96 (4), pp. 12992. Date of Electronic Publication: 2024 Nov 11. |
| DOI: | 10.4081/aiua.2024.12992 |
| Abstrakt: | Introduction: To evaluate the detection rate for prostate cancer (PCa) performing multiparametric magnetic resonance imaging (mpMRI) fusion targeted biopsy (TPBx) combined only with ipsilateral systematic prostate biopsy (SPBx). Materials and Methods: From January 2023 to December 2023, 495 men with clinical suspicion of PCa underwent transperineal SPBx plus TPBx in the presence of PI-RADS score lesions ≥ 3. Results: In 250/495 men (50.5%) a PCa was found, while 36/250 (14.4%) men had negative mpMRI. In comparison to TPBx, SPBx diagnosed a higher number of indolent PCa, 38.5 vs. 5.8%, respectively; conversely, SPBx demonstrated a higher detection rate for clinically significant PCa (97.3 vs. 85.4%) in the presence of ISUP Grade Group 2 (GG2). In details, rates were higher in the presence of GG2 (100 vs. 76%), GG3 (85.7 vs. 75.8%) and GG4 (100 vs. 86.4%) tumors. However, in GG5, both SPBx and TPBx diagnosed 100% of csPCa. Furthermore, 89.4% of the cases showed csPCa on the negative mpMRI side. Conclusions: SPBx combined with TPBx maximized csPCa diagnosis; the use of reduced biopsy scheme limited to ipsilateral side of mpMRI lesion plus TPBx missed 11.6% csPCa. Only in the presence of PI-RADS score 5 SPBx and TPBx diagnosed both 100% of csPCa. |
| Databáze: | MEDLINE |
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