Post-COVID-19 inflammation and sarcopenia in obese diabetic dialysis patients.

Autor: de Oliveira CAF; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil., Amaral LMB; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil., Micheleto JPC; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil., Melo KA; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil., de Medeiros Rijo M; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil., Lira PGB; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil., de Oliveira Barreto E; Institute of Biological Science, Federal University of Alagoas, Maceió, Brazil., da Silva JP; Institute of Biological Science, Federal University of Alagoas, Maceió, Brazil., Caetano AFP; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil.; Institute of Physical Education and Sports, Federal University of Alagoas, Maceió, Brazil., de Farias Santos JC; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil.; Faculty of Nutrition, Federal University of Alagoas, Maceió, Brazil., Oliveira MJC; Faculty of Medicine, Federal University of Alagoas, Maceió, Brazil.
Jazyk: angličtina
Zdroj: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy [Ther Apher Dial] 2024 Dec 18. Date of Electronic Publication: 2024 Dec 18.
DOI: 10.1111/1744-9987.14237
Abstrakt: Introduction: Diabetes, obesity, and CKD collectively impact musculoskeletal health and increase the risk of severe coronavirus disease 2019 (COVID-19) outcomes.
Methods: This cross-sectional study included 32 dialysis patients, categorized based on their COVID-19 status. Laboratory assessments included inflammatory markers (IL-1β, IL-6, IL-8, and TNF-α). Sarcopenia risk was evaluated using the strength, assistance with walking, rising from a chair, climbing stairs, and falls (SARC-F) questionnaire, bioimpedance analysis, and static muscle strength testing.
Results: No significant differences were observed between groups in laboratory values, sarcopenia risk, or inflammatory markers. Body composition, SARC-F scores, and static muscle strength were comparable across both groups, except for elevated parathyroid hormone (PTH) levels in Group A (p = 0.008).
Conclusion: The lack of association between the inflammatory response and sarcopenia risk may be attributed to the existing inflammatory status of this population, given the coexistence of diabetes, CKD, and obesity. Notably, all studied laboratory variables showed no significant differences, except for the higher PTH levels.
(© 2024 International Society for Apheresis and Japanese Society for Apheresis.)
Databáze: MEDLINE
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