Enteropathy-associated T-cell lymphoma: A population-based cohort study on incidence, treatment, and outcome in the Netherlands.

Autor: Meeuwes FO; Department of Hematology University Medical Center Groningen Groningen the Netherlands.; Department of Hematology Medisch Spectrum Twente Enschede the Netherlands., Brink M; Department of Hematology University Medical Center Groningen Groningen the Netherlands.; Department of Research and Development Netherlands Comprehensive Cancer Organization (IKNL) Utrecht the Netherlands., Plattel WJ; Department of Hematology Medisch Spectrum Twente Enschede the Netherlands., Vermaat JSP; Department of Hematology Leiden University Medical Center Leiden the Netherlands., Kersten MJ; Department of Hematology Amsterdam University Medical Center, Cancer Center Amsterdam University of Amsterdam Amsterdam the Netherlands., Wondergem M; Department of Hematology Amsterdam University Medical Center, Cancer Center Amsterdam University of Amsterdam Amsterdam the Netherlands., Visser O; Department of Hematology Isala Hospital Zwolle the Netherlands., van der Poel MWM; Department of Internal Medicine Division of Hematology GROW School for Oncology and Developmental Biology, Maastricht University Medical Center Maastricht the Netherlands., Oostvogels R; Department of Hematology University Medical Center Utrecht Utrecht the Netherlands., Woei-A-Jin FJSH; Department of General Medical Oncology University Hospitals Leuven Leuven Belgium., Böhmer L; Department of Hematology Haga Teaching Hospital the Hague the Netherlands., Snijders TJF; Department of Hematology Medisch Spectrum Twente Enschede the Netherlands., Huls GA; Department of Hematology University Medical Center Groningen Groningen the Netherlands., Nijland M; Department of Hematology University Medical Center Groningen Groningen the Netherlands.
Jazyk: angličtina
Zdroj: EJHaem [EJHaem] 2024 Nov 29; Vol. 5 (6), pp. 1215-1222. Date of Electronic Publication: 2024 Nov 29 (Print Publication: 2024).
DOI: 10.1002/jha2.1049
Abstrakt: Introduction: Enteropathy-associated T-cell lymphoma (EATL) is a peripheral T-cell lymphoma (PTCL) with a poor prognosis. Cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with or without etoposide consolidated by autologous stem cell transplantation (ASCT) are recommended for fit PTCL patients. The role of etoposide and ASCT in EATL is unclear.
Methods: This study reports the incidence, treatment, and outcome of EATL patients using the Netherlands Cancer Registry, with nationwide coverage of >95%.
Results: All patients diagnosed in 1989-2021 ( n  = 351, 77% treated) were identified (median age 67 years, 56% male, 50% limited stage). Time period analysis assessed trends in primary therapy and overall survival (OS). Treatment included chemotherapy (CT) (34%), surgery (18%), surgery and CT (19%) or CT followed by ASCT (7%). The 5-year OS for treated patients with limited versus advanced stage was 19% and 9% respectively. The 2-year OS improved over time (21%-33%, p =  0.06). Surgery only (hazard ratio [HR] 2.16; 95% confidence interval [CI] 1.55-3.01, p <  0.01) and advanced-stage disease (HR 1.67; 95% CI 1.25-2.23, p =  0.01) were predictors of poor prognosis. ASCT (HR 0.31; 95% CI 0.18-0.56) was associated with improved OS.
Conclusion: There was no statistical difference in OS between patients treated with or without etoposide. Current first-line treatment is ineffective.
Competing Interests: The authors declare no conflict of interest.
(© 2024 The Author(s). eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.)
Databáze: MEDLINE
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