An Interior/Exterior Collaboration-Enhanced Intestinal Anastomosis (IECIA) for Multi-Tiered Leakage Complication Management.

Autor: Chen X; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Gong Y; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Li M; Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology, Wuhan, 430022, China., Zeng Q; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Xu R; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Huazhong University of Science and Technology, Wuhan, 430022, China., Li X; Key Laboratory of Material Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China., Lu X; Key Laboratory of Material Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China., Gong S; School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Ave, Singapore, 639798, Singapore., Xu J; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Li G; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Yang J; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Jiao W; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Liu J; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Liu Y; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Liang X; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., He L; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China., Xiao F; Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, China., Chen W; Department of Pharmacology, School of Basic Medicine, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Tongji-Rongcheng Center for Biomedicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.; Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation Huazhong University of Science and Technology, Wuhan, 430030, China.
Jazyk: angličtina
Zdroj: Small (Weinheim an der Bergstrasse, Germany) [Small] 2024 Dec 17, pp. e2408222. Date of Electronic Publication: 2024 Dec 17.
DOI: 10.1002/smll.202408222
Abstrakt: Anastomotic leakage (AL) is a pervasive and risky postoperative complication that presently features inaccessible prevention, delayed diagnosis, and intractable remediation, resulting in distressing morbidity and mortality. Herein an interior/exterior collaboration-enhanced neoteric intestinal anastomosis (IECIA) is developed, which consists of an interior hydrogel-based protective barrier adhering to mucosa, and exterior synergistic leakage-prevention safeguard sutured to serosa, for multi-tiered leakage complication management. Noticeably, the hydrogel barrier protects anastomosis stoma against injurious stimulation from digestive liquid, consequently reducing leakage risk effectively and comfortably in place of painful gastric tube insertion. The exterior safeguard encompassing fluorescein-loaded hydrogel and electrospun film functions as a secondary defense, exhibiting critical leakage-prevention capability to refrain from lethal intra-abdominal infection. Meanwhile, fluorescein is released to the enteric cavity for following detection within the excrement in case anastomotic leakage occurs, achieving presymptomatic alarming in providing valuable prompts for timely clinical intervention. Importantly, IECIA has been investigated in realistic in vivo end-to-end intestinal anastomosis scenarios as well as simulated leakage models, which present satisfactory postoperative recovery of gastrointestinal functions and systematic indexes. Moreover, the IECIA system is endowed with guaranteed biocompatibility, effective durability, comprehensibility for surgical operation, comfort, and compliance for patients, which demonstrates precious value for clinical translation.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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