Sonographic bleb visualisation after PAUL glaucoma implant surgery.

Autor:	Weber C; Department of Ophthalmology, University of Bonn, Bonn, Germany constance.weber@ukbonn.de., Weinhold L; Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany., Walz W; Department of Ophthalmology, University of Bonn, Bonn, Germany., Petrak M; Department of Ophthalmology, University of Bonn, Bonn, Germany., Holz FG; Department of Ophthalmology, University of Bonn, Bonn, Germany., Liegl R; Department of Ophthalmology, University of Bonn, Bonn, Germany., Mercieca K; Department of Ophthalmology, University of Bonn, Bonn, Germany.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2024 Dec 16. Date of Electronic Publication: 2024 Dec 16.
DOI:	10.1136/bjo-2024-326168
Abstrakt:	Background/aims: Bleb characteristics in the area around the plate following glaucoma drainage device (GDD) surgery are difficult to evaluate on slit lamp examination. Ultrasound sonography could be used for more detailed visualisation. The aim of this study was to describe bleb configuration after PAUL glaucoma implant (PGI) surgery and evaluate the possible correlation with intraocular pressure (IOP) in order to derive new markers for evaluating GDD function. Methods: Patients underwent a 15 MHz ultrasound examination (Compact Touch, Quantel Medical) after undergoing PGI implantation. The filtering bleb dimensions were measured and bleb configuration was assessed along with documentation of all clinical data. Results: A total of 70 eyes from 65 patients were included. 55 eyes (78.6%) had a double-layered bleb whereas 15 eyes (21.4%) had a bleb with only one compartment (six eyes, 8.6% above; nine eyes, 12.9% below the plate). The total height of both compartments averaged 3.52 mm. The average IOP was 13.03 mm Hg. There was a significant correlation between single and double-layered blebs (p<0.01) with regard to IOP (one compartment: 16.47 mm Hg vs two compartments: 12.09 mm Hg). There was no significant correlation between total bleb height (p=0.143) or bleb extension (T: p=0.629; L: p=0.742). However, total bleb height showed an inverse association with IOP. Blebs with a height >2 mm had significantly lower mean IOP than those having <2 mm bleb heights (p=0.041). Conclusions: Sonography is a suitable modality to evaluate bleb characteristics after PGI implantation. Blebs with a double fluid layer are significantly correlated with lower IOP values. Bleb height has an inverse association with IOP, with higher blebs (>2 mm) showing a significantly lower IOP. Competing Interests: Competing interests: CW, LW, MP and RL certify that they have no affiliations with or involvement in any organisation or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership or other equity interest and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript. KM has received honoraria or research grants from the following: Allergan/Abbvie (C,H,R) and Glaukos (C,H,R), but none of this is related to the current study. FGH has received honoraria or research grants from the following: Acucela (C,F), Allergan (F), Apellis (C, F), Bayer (C, F), Boehringer-Ingelheim (C), Bioeq/ Formycon (F,C), CenterVue (F), Ellex (F), Roche/Genentech (C,F), Geuder (C,F), Graybug (C), Gyroscope (C), Heidelberg Engineering (C,F), IvericBio (C, F), Kanghong (C,F), LinBioscience (C), NightStarX (F), Novartis (C,F), Optos (F), Oxurion (C), Pixium Vision (C,F), Oxurion (C), Stealth BioTherapeutics (C), Zeiss (F,C), but none of this is related to the current study. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ Group.)
Databáze:	MEDLINE
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