Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.

Autor: Jeong H; Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America., Luo T; Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America., Kang M; Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America., Garvey WF; School of Psychology, University of Sheffield, Cathedral Court, 1 Vicar Lane, Sheffield, S1 2LT, United Kingdom., Blankenau G; Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America., Suk JW; Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, South Korea., Tarzaben M; Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America., Hwang S; Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America. Electronic address: soonjo.hwang@unmc.edu.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2024 Dec 05; Vol. 347, pp. 111917. Date of Electronic Publication: 2024 Dec 05.
DOI: 10.1016/j.pscychresns.2024.111917
Abstrakt: This review examines neuroimaging studies on adolescent depression (AD) within the Research Domain Criteria (RDoC) framework, focusing on fMRI, DTI, and EEG findings. The research highlights disrupted connectivity in several neural networks-such as the affective, reward processing, cognitive control, and default mode networks-that underpin emotional and cognitive dysfunctions in AD. Notably, hypoconnectivity in the affective and cognitive control networks correlates with deficits in emotional processing and executive functioning, while hyperactivity in the default mode network relates to excessive self-referential thoughts. Additionally, blunted reward responses and frontal-striatal connectivity are discussed alongside the therapeutic potential of cognitive behavioral therapy (CBT) to modulate these dysfunctional circuits. Despite these insights, variability in findings due to small sample sizes and diverse methodologies suggests a need for further research to validate neuroimaging biomarkers for treatment efficacy and to explore less studied treatments like ECT and TMS in this population. This review underscores the importance of integrating neuroimaging findings to enhance understanding and treatment of AD.
Competing Interests: Declaration of competing interest All authors declare that they have no conflicts of interest to report regarding this study.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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