Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

Autor: Gupta J; Institute of Pharmaceutical Research, GLA University, Mathura, UP 281406, India. Electronic address: smartjitu79@gmail.com., Abosaoda MK; College of Pharmacy, The Islamic University, Najaf, Iraq; College of Pharmacy, The Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq; College of Pharmacy, The Islamic University of Babylon, Babylon, Babylon, Iraq., Shukla M; Marwadi University Research Center, Department of Computer Engineering, Faculty of Engineering & Technology, Marwadi ‎University, Rajkot, Gujarat 360003, India., Ballal S; Department of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be ‎University), Bangalore, Karnataka, India., Kumar A; School of Pharmacy-Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University, Gangoh, Uttar Pradesh 247341, India; Department of Pharmacy, Arka Jain University, Jamshedpur, Jharkhand 831001, India., Chahar M; Department of Chemistry, NIMS Institute of Engineering & Technology, NIMS University ‎Rajasthan, Jaipur, India., Saini S; Department of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of ‎Colleges, Jhanjeri, Mohali, Punjab 140307, India., Kapila I; Centre for Research Impact & Outcome, Chitkara University Institute of Engineering and ‎Technology, Chitkara University, Rajpura, Punjab 140401, India., Hadpoori A; Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: alihadpour1985@gmail.com.
Jazyk: angličtina
Zdroj: Prostaglandins & other lipid mediators [Prostaglandins Other Lipid Mediat] 2024 Dec 16; Vol. 176, pp. 106939. Date of Electronic Publication: 2024 Dec 16.
DOI: 10.1016/j.prostaglandins.2024.106939
Abstrakt: Background: There is no consensus in the existing literature regarding the effect of soluble fiber on the lipid profile of patients with type 2 diabetes mellitus (T2DM). This systematic review and meta-analysis of randomized controlled trials aimed to assess the effect of soluble fiber on triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in T2DM patients.
Methods: PubMed/MEDLINE, Scopus, and ISI Web of sciences were searched for RCTs up to 4 May 2024. Data from RCTs were pooled using the generic inverse variance method and expressed as weighted mean differences (WMD) with 95 % confidence interval (CIs).
Results: Pooled data from 38 RCTs reporting patient outcomes were evaluated for mean effects. Results indicated that soluble fiber significantly altered TG (WMD: -16.97 mg/dL, 95 % CI: -29.16 to -4.78, P = 0.021), HDL-C (WMD: 1.74 mg/dL, 95 % CI: 1.02-2.46, P < 0.001), LDL-C (WMD: -11.14 mg/dL, 95 % CI: -15.41 to -6.87, P < 0.001), and TC (WMD: -13.87 mg/dL, 95 % CI: -17.99 to -9.75, P = 0.027).
Conclusions: Soluble fiber supplementation has the potential to improve lipid profile in patients with T2DM, and may provide a feasible approach for improving metabolic health in T2DM patients.
Competing Interests: Conflict of Interest There are no conflicts to declare.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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