Nature or nurture: genetic and environmental predictors of adiposity gain in adults.

Autor:	Peruchet-Noray L; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain., Dimou N; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France., Cordova R; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France; Department of Nutritional Sciences, University of Vienna, Vienna, Austria., Fontvieille E; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France., Jansana A; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France., Gan Q; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France., Breeur M; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France., Baurecht H; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Bohmann P; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Konzok J; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Stein MJ; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany., Dahm CC; Department of Public Health, Aarhus University, Aarhus, Denmark., Zilhão NR; Department of Public Health, Aarhus University, Aarhus, Denmark., Mellemkjær L; Danish Cancer Society Research Center, Copenhagen, Denmark., Tjønneland A; Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, The University of Copenhagen, Copenhagen, Denmark., Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Katzke V; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany., Inan-Eroglu E; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany., Schulze MB; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, German., Masala G; Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy., Sieri S; Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori Di Milano, Milan, Italy., Simeon V; Department of Mental and Physical Health and Preventive Medicine, University 'Luigi Vanvitelli', Naples, Italy., Matullo G; Department of Medical Sciences, University of Torino, Italy; Genetic Service Unit, Città della Salute e della Scienza di Torino, Italy., Molina-Montes E; Department of Nutrition and Food Science, Campus of Cartuja, University of Granada, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, 18012, Granada, Spain; Institute of Nutrition and Food Technology (INYTA) 'José Mataix', Biomedical Research Centre, University of Granada, 18071, Granada, Spain., Amiano P; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; BioGipuzkoa (BioDonostia) Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain., Chirlaque MD; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Murcia, Spain., Gasque A; Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain., Atkins J; Cancer Epidemiology Unit, University of Oxford, Oxford, UK., Smith-Byrne K; Cancer Epidemiology Unit, University of Oxford, Oxford, UK., Ferrari P; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France., Viallon V; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France., Agudo A; Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908, L'Hospitalet de Llobregat, Spain., Gunter MJ; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, United Kingdom., Bonet C; Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908, L'Hospitalet de Llobregat, Spain., Freisling H; International Agency for Research on Cancer (IARC/WHO), Nutrition and Metabolism Branch, 69366, Lyon CEDEX 07, France. Electronic address: freislingh@iarc.who.int., Carreras-Torres R; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), 17190, Salt, Girona, Spain. Electronic address: rcarreras@idibgi.org.
Jazyk:	angličtina
Zdroj:	EBioMedicine [EBioMedicine] 2024 Dec 16; Vol. 111, pp. 105510. Date of Electronic Publication: 2024 Dec 16.
DOI:	10.1016/j.ebiom.2024.105510
Abstrakt:	Background: Previous prediction models for adiposity gain have not yet achieved sufficient predictive ability for clinical relevance. We investigated whether traditional and genetic factors accurately predict adiposity gain. Methods: A 5-year gain of ≥5% in body mass index (BMI) and waist-to-hip ratio (WHR) from baseline were predicted in mid-late adulthood individuals (median of 55 years old at baseline). Proportional hazards models were fitted in 245,699 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort to identify robust environmental predictors. Polygenic risk scores (PRS) of 5 proxies of adiposity [BMI, WHR, and three body shape phenotypes (PCs)] were computed using genetic weights from an independent cohort (UK Biobank). Environmental and genetic models were validated in 29,953 EPIC participants. Findings: Environmental models presented a remarkable predictive ability (AUC BMI : 0.69, 95% CI: 0.68-0.70; AUC WHR : 0.75, 95% CI: 0.74-0.77). The genetic geographic distribution for WHR and PC1 (overall adiposity) showed higher predisposition in North than South Europe. Predictive ability of PRSs was null (AUC: ∼0.52) and did not improve when combined with environmental models. However, PRSs of BMI and PC1 showed some prediction ability for BMI gain from self-reported BMI at 20 years old to baseline observation (early adulthood) (AUC: 0.60-0.62). Interpretation: Our study indicates that environmental models to discriminate European individuals at higher risk of adiposity gain can be integrated in standard prevention protocols. PRSs may play a robust role in predicting adiposity gain at early rather than mid-late adulthood suggesting a more important role of genetic factors in this life period. Funding: French National Cancer Institute (INCA_N°2019-176) 1220, German Research Foundation (BA 5459/2-1), Instituto de Salud Carlos III (Miguel Servet Program CP21/00058). Competing Interests: Declaration of interests L.M. discloses that an immediate family member holds stocks in Novo Nordisk. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2024. Published by Elsevier B.V.)
Databáze:	MEDLINE
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