Evaluating the Antimalarial Potential of d-α-Tocopherol Polyethylene Glycol 1000 Succinate and α-Tocopherol, In Vivo Studies in Plasmodium berghei-Infected Mice and Molecular Docking Insights.

Autor: Dos Santos Guimarães M; Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil., Varela ELP; Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.; Postgraduate Program in Biodiversity and Biotechnology-BIONORTE Network, Federal University of Pará, Belém, Pará, Brazil., Quadros Gomes AR; Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil., de Carvalho EP; Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.; Postgraduate Program in Biodiversity and Biotechnology-BIONORTE Network, Federal University of Pará, Belém, Pará, Brazil., Ferreira OO; Adolpho Ducke Laboratory, Botany Coordination, Museu Paraense Emílio Goeldi, Belém, Pará, Brazil., Horchani M; Faculty of Sciences of Monastir, Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products (LR11ES39), University of Monastir, Monastir, Tunisia., Edziri H; Faculty of Pharmacy, Laboratory of Transmissible Diseases and Biologically Active Substances, University of Monastir, Monastir, Tunisia., Andrade EHA; Postgraduate Program in Biodiversity and Biotechnology-BIONORTE Network, Federal University of Pará, Belém, Pará, Brazil.; Adolpho Ducke Laboratory, Botany Coordination, Museu Paraense Emílio Goeldi, Belém, Pará, Brazil., de Oliveira MS; Adolpho Ducke Laboratory, Botany Coordination, Museu Paraense Emílio Goeldi, Belém, Pará, Brazil., Percário S; Oxidative Stress Research Laboratory, Institute of Biological Sciences, Federal University of Pará, Belém, Pará, Brazil.; Postgraduate Program in Biodiversity and Biotechnology-BIONORTE Network, Federal University of Pará, Belém, Pará, Brazil.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Dec 17, pp. e202402297. Date of Electronic Publication: 2024 Dec 17.
DOI: 10.1002/cbdv.202402297
Abstrakt: Oxidative stress is a pivotal factor in the pathogenesis of malaria, contributing to the development of conditions such as anemia, respiratory complications, and cerebral malaria. To counteract oxidative damage, we evaluated the effects of vitamin E (α-TOH) and d-α-tocopherol polyethylene glycol 1000 succinate (TPGS) supplementation on parasitemia progression, mortality rate, and blood-brain barrier (BBB) permeability in Plasmodium berghei ANKA-infected mice. The mice were divided into four groups: a control group (untreated and uninfected), an infected group (Pb), a TPGS + Pb group, and an α-TOH + Pb group. The results demonstrated that TPGS was more effective than α-TOH, exhibiting a lower parasitemia (9.59%) and mortality (40%) by Day 12 and superior BBB protection in advanced infection stages. These findings suggest that TPGS may represent a promising therapeutic strategy for the management of malaria. Molecular docking analysis indicated that TPGS exhibited the highest binding affinity with plasmepsin 2 (-7.3 kcal/mol), whereas vitamin E demonstrated the strongest binding with plasmepsin 1 (-7.2 kcal/mol).
(© 2024 Wiley‐VHCA AG, Zurich, Switzerland.)
Databáze: MEDLINE
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