Association of type 2 diabetes mellitus with sensorineural hearing loss - A population-based analysis.

Autor:	Li M; Sidney Kimmel Medical College, Thomas Jefferson University, USA., Perlov NM; Sidney Kimmel Medical College, Thomas Jefferson University, USA., Patel J; Department of Otolaryngology, Thomas Jefferson University Hospital, USA., Amin D; Department of Otolaryngology, Thomas Jefferson University Hospital, USA., Kumar A; Department of Otolaryngology, Thomas Jefferson University Hospital, USA., Urdang ZD; Department of Otolaryngology, Thomas Jefferson University Hospital, USA., Willcox TO; Department of Otolaryngology, Thomas Jefferson University Hospital, USA., Chiffer RC; Department of Otolaryngology, Thomas Jefferson University Hospital, USA.
Jazyk:	angličtina
Zdroj:	Neuro endocrinology letters [Neuro Endocrinol Lett] 2024 Nov 28; Vol. 45 (5), pp. 341-351. Date of Electronic Publication: 2024 Nov 28.
Abstrakt:	Objective: To test the hypothesis that patients with poorly controlled type 2 diabetes mellitus are more likely to develop sensorineural hearing loss (SNHL) than non-diabetic patients. Study Design: Retrospective cohort study. Setting: TriNetX US Collaborative Network (2003-2022). Methods: Electronic medical record data from the TriNetX US Collaborative Network was queried for subjects without prior hearing loss, defined using medical billing codes (ICD-10, CPT, etc.), who were diagnosed with type 2 diabetes mellitus after January 2003. Patients were stratified by most recent HbA1c (8.0-13.9% or ≥14.0%) and by age at diagnosis (21-30, 31-40, 41-50, 51-60, 61-70, ≥71 years). Primary outcome was development of SNHL ≤20 years after diabetes diagnosis. Cohorts were propensity-score matched for age, gender, race, and hearing loss-related conditions, including vascular disease and tobacco/nicotine use. Hearing loss risk in each cohort were compared against age-matched non-diabetic subjects. Results: All diabetic patients had greater risk of SNHL compared to age-matched controls; having a higher HbA1c (≥14.0%) additionally associated with greater risk than a lower HbA1c (8.0-13.9%) for all age groups except 21-30 and 31-40 years. Furthermore, risk was higher for older patients of both HbA1c ranges, with patients ≥71 years at diagnosis having greatest risk. Patients ≥71 with HbA1c ≥14.0% (n = 3,870) had a 0.51% (95% confidence interval: 0.28-0.74, p < 0.0001) greater hearing loss risk, and patients with HbA1c 8.0-13.9% (n = 155,066) had 0.24% (0.22-0.27, p < 0.0001) greater risk. Conclusion: Type 2 diabetes diagnosis appears to strongly associate with greater risk of developing SNHL, especially in older patients. Audiometric screening may be warranted.
Databáze:	MEDLINE
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