Efficacy of Oral Sulfate Tablet and 2 L-Polyethylene Glycol With Ascorbic Acid for Bowel Preparation: A Prospective Randomized KASID Multicenter Trial.

Autor:	Jung Y; Department of Internal Medicine, Soonchunhyang University College of Medicine, Cheonan, Korea., Kim HG; Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea. medgun@schmc.ac.kr., Yang DH; Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea., Kang HW; Department of Gastroenterology, Seoul National University Boramae Medical Center, Seoul, Korea., Park JJ; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Baek DH; Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea., Chun J; Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea., Gweon TG; Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea., Goong HJ; Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea., Kwak MS; Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, Seoul, Korea., Lee HJ; Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea., Park SK; Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea., Lee JH; Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.
Jazyk:	angličtina
Zdroj:	Journal of Korean medical science [J Korean Med Sci] 2024 Dec 16; Vol. 39 (48), pp. e301. Date of Electronic Publication: 2024 Dec 16.
DOI:	10.3346/jkms.2024.39.e301
Abstrakt:	Background: Oral sulfate tablets (OSTs) are bowel preparation agents that combine oral sulfate solution and simethicone. This study compared the efficacy, tolerability, and safety of OST compared to 2 L-polyethylene glycol plus ascorbic acid (2 L-PEG/ASC). Methods: This prospective, randomized, controlled, single-blinded, multicenter, noninferiority trial enrolled 211 healthy adults who underwent colonoscopy between May 2020 and September 2022 at 13 university hospitals. The bowel cleansing rate was assessed using the Boston Bowel Preparation Scale (BBPS) and Harefield Cleansing Scale (HCS), and the preparation agents were administered in split regimens. Results: The total BBPS score (8.2 ± 1.5 vs. 7.8 ± 1.4, p = 0.040) and the high-quality bowel cleansing rates in the right colon (73.2% vs. 50.5), transverse colon (80.6% vs. 68.0%), and left colon (81.5% vs. 67.0%) on the BBPS were significantly higher in the OST group than in the 2 L-PEG/ASC group. However, the rates of successful cleansing according to BBPS (90.7% vs. 91.2%) and HCS (96.3% vs. 94.2%) did not significantly differ between the two groups. The taste, ease, and amount of consumption of the preparation agent; and willingness to repeat colonoscopy with the same agent (89.8% vs. 78.6%, P = 0.026) were significantly better in the OST group compared to the 2 L-PEG/ASC group. Adverse events and clinically significant laboratory changes were not significantly different between the two groups. Conclusion: The OST was not inferior to 2 L-PEG/ASC in terms of bowel cleansing efficacy and showed better tolerability when used for bowel preparation for colonoscopy. Trial Registration: Clinical Research Information Service Identifier: KCT0005017. Competing Interests: The authors have no potential conflicts of interest to disclose. (© 2024 The Korean Academy of Medical Sciences.)
Databáze:	MEDLINE
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