Prognostic Effect of Patterns of Local Extension and Satellitosis in cT3 Squamous Cell Carcinoma of the Oral Tongue: A Prospective Observational Study.

Autor: Montalto N; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy., Battocchio S; Unit of Pathology, ASST Spedali Civili di Brescia, Brescia, Italy., Contro G; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Technology for Health (PhD Program), Department of Information Engineering, University of Brescia, Brescia, Italy., Gaudioso P; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Padova, Italy., Mularoni F; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy., Ruaro A; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Guided Therapeutics (GTx) Program International Scholarship, University Health Network (UHN), Toronto, Ontario, Canada., Ramacciotti G; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy., Cazzador D; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy., Spinato G; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Padova, Italy., Carobbio ALC; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy., Taboni S; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Guided Therapeutics (GTx) Program International Scholarship, University Health Network (UHN), Toronto, Ontario, Canada., Zanoletti E; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Padova, Italy., Piazza C; Unit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili di Brescia, Brescia, Italy.; Department of Surgical and Medical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy., Nicolai P; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Padova, Italy., Ferrari M; Unit of Otorhinolaryngology-Head and Neck Surgery, Azienda Ospedale Università di Padova, Padova, Italy.; Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neurosciences, University of Padua, Padova, Italy.; Guided Therapeutics (GTx) Program International Scholarship, University Health Network (UHN), Toronto, Ontario, Canada.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2024 Dec 17. Date of Electronic Publication: 2024 Dec 17.
DOI: 10.1002/hed.28025
Abstrakt: Introduction: The anatomy of the tongue is three-dimensionally complex and is thought to play a central role in the local growth of oral tongue squamous cell carcinoma (OTSCC). Understanding patterns of tumor extension could improve a multimodal therapeutic approach. Thus, the main aim of this study was to provide a histological and microanatomical analysis of surgical specimens after compartmental surgery for OTSCC.
Materials and Methods: The present prospective observational study included primary cT3 OTSCC (according to the eighth edition of the TNM classification) treated in an academic tertiary referral center with curative compartmental surgery, from July 2016 to July 2019. Analysis of histologic macrosections allowed assessment of standard pathologic parameters as well as a detailed analysis of the position of OTSCC cells from microanatomic and topographic standpoints.
Results: Of the 28 patients included, 71.4% were males, with a mean age of 64.9 years. Nine (32.1%) patients presented satellitosis, which was always located within the T-N tract. OTSCCs displaying satellitosis had a significantly higher median pathologic depth of invasion (DOI). A radiologic and pathological DOI > 15 mm significantly predicted the presence of satellites. There was a significant relationship between the presence of satellites and both positive lymph nodes and distant metastases.
Conclusion: Approximately one-third of cases of intermediate-to-advanced OTSCC are characterized by tumor satellites located in the T-N tract. DOI exceeding 15 mm and the presence of clinically appreciable nodal metastases best predict the presence of satellitosis. Satellite-bearing OTSCC behave more aggressively, with an increased risk of distant metastasis and reduced survival.
(© 2024 The Author(s). Head & Neck published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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