U-Shaped Relationship Between MSpO 2 Levels and the Incidence of Frailty in Elderly OSA Patients: Findings from a Multicenter Cohort Study.

Autor: Xue X; Department of Pulmonary and Critical Care Medicine of the Second Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China., Zhao Z; Department of Vasculocardiology, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China., Zhao LB; Department of Vasculocardiology, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China., Gao YH; PKU-Upenn Sleep Center, Peking University International Hospital, Beijing, People's Republic of China., Xu WH; Department of Geriatrics, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, People's Republic of China., Cai WM; Department of Pulmonary and Critical Care Medicine, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China., Chen SH; Department of Pulmonary and Critical Care Medicine, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China., Li TJ; Medical College, Yan' an University, Yan' an, People's Republic of China., Nie TY; Medical College, Yan' an University, Yan' an, People's Republic of China., Rui D; Department of Pulmonary and Critical Care Medicine, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China., Ma Y; Department of Pulmonary and Critical Care Medicine, Second Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China., Qian XS; Department of Pulmonary and Critical Care Medicine of the Second Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China., Lin JL; Department of Respiratory and Critical Care Medicine, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China., Liu L; Department of Pulmonary and Critical Care Medicine of the Second Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China.
Jazyk: angličtina
Zdroj: Clinical interventions in aging [Clin Interv Aging] 2024 Dec 12; Vol. 19, pp. 2109-2119. Date of Electronic Publication: 2024 Dec 12 (Print Publication: 2024).
DOI: 10.2147/CIA.S489962
Abstrakt: Background: Previous studies have demonstrated a significant correlation between obstructive sleep apnea (OSA) and frailty. However, the association of mean pulse oxygen saturation (MSpO 2 ) with frailty among OSA patients remains unconfirmed. This study aimed to explore this potential association using data from a multicenter, prospective cohort.
Methods: A total of 1006 elderly patients diagnosed with OSA through polysomnography (PSG) from January 2015 to October 2017 were enrolled. Patients were stratified into four groups according to their MSpO 2 levels to assess differences in frailty onset. Multivariate Cox regression analysis, Kaplan-Meier curves, restricted cubic splines, and subgroup analyses were employed to evaluate variations in frailty onset across different MSpO 2 levels.
Results: Over a median follow-up period of 52 months, 275 patients developed frailty. Analysis using restricted cubic splines revealed a U-shaped trend between MSpO 2 and frailty risk (non-linear p- value = 0.028). Patients in the lowest quartile (MSpO 2  < 91.6%) exhibited a higher risk of frailty (hazard ratio [HR] = 1.43, 95% confidence interval [CI] 1.03-1.97, P = 0.029) compared to those in the third quartile (MSpO 2 93-95%). Subgroup and sensitivity analyses confirmed the robustness of the U-shaped relationship.
Conclusion: There is a U-shaped association between MSpO 2 and frailty among patients with OSA. Enhancing MSpO 2 levels may mitigate the risk of frailty and improve prognosis in this population.
Competing Interests: There were no potential conflicts of interest in the study, according to the authors.
(© 2024 Xue et al.)
Databáze: MEDLINE
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