Maternal genomic profile, gestational diabetes control, and Mediterranean diet to prevent low birth weight.

Autor:	Ramos-Levi AM; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain.; Facultad de Medicina. Medicina II Department, Universidad Complutense de Madrid, Spain. Av. Complutense, 28040 Madrid, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., O'Connor RM; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Barabash A; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain.; Facultad de Medicina. Medicina II Department, Universidad Complutense de Madrid, Spain. Av. Complutense, 28040 Madrid, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., de Miguel MP; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain.; Facultad de Medicina. Medicina II Department, Universidad Complutense de Madrid, Spain. Av. Complutense, 28040 Madrid, Spain., Diaz-Perez A; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain.; Facultad de Medicina. Medicina II Department, Universidad Complutense de Madrid, Spain. Av. Complutense, 28040 Madrid, Spain., Marcuello C; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Familiar C; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Moraga I; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Arnoriaga-Rodriguez M; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Valerio J; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Valle LD; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Melero V; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Zulueta M; Patia Europe, Clinical Laboratory, Paseo Mikeletegi 69, San Sebastián, Spain., Mendizabal L; Patia Europe, Clinical Laboratory, Paseo Mikeletegi 69, San Sebastián, Spain., Torrejon MJ; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain., Rubio MA; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain.; Facultad de Medicina. Medicina II Department, Universidad Complutense de Madrid, Spain. Av. Complutense, 28040 Madrid, Spain., Matia-Martín P; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain.; Facultad de Medicina. Medicina II Department, Universidad Complutense de Madrid, Spain. Av. Complutense, 28040 Madrid, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain., Calle-Pascual A; Department of Endocrinology and Nutrition, Hospital Clínico Universitario San Carlos and Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. Calle Profesor Martin Lagos s/n, 28040 Madrid, Spain.; Facultad de Medicina. Medicina II Department, Universidad Complutense de Madrid, Spain. Av. Complutense, 28040 Madrid, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Madrid, Spain.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Nov 13; Vol. 27 (12), pp. 111376. Date of Electronic Publication: 2024 Nov 13 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.111376
Abstrakt:	Low birth weight (LBW) is associated to poor health outcomes. Its causes include maternal lifestyle, obstetric factors, and fetal (epi)genetic abnormalities. This study aims to increase the knowledge regarding the genetic background of LBW by analyzing its association with a set of 110 maternal variants related to gestational diabetes mellitus, in the setting of a nutritional intervention with Mediterranean diet. The analysis follows a multifactorial approach, including maternal genetic information of 1,642 pregnant women, along with their anthropometric and metabolic characteristics. Binary logistic regression models provided 33 discovery variants associated with LBW that underwent a functional enrichment process to obtain a protein/gene interaction network and 126 enriched terms. Overall, our analysis proves that genetic variants form proximity clusters, grouped into subsets statistically associated with underlying biological processes or other maternal characteristics, which, on their part, allow early prevention of the eventual risk of LBW. Competing Interests: The authors declare no competing interests. (© 2024 The Author(s).)
Databáze:	MEDLINE
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