Immune Profile and MRI-Detected Cardiac Fibrosis and Edema in Hypertensive and Non-Hypertensive Patients with COVID-19.

Autor: Moll-Bernardes R; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil., Camargo GC; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil., Silvestre-Sousa A; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Evandro Chagas National Institute of Infectious Disease, Oswaldo Cruz Foundation, Rio de Janeiro 21040-360, Brazil., Barroso JM; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil., Ferreira JR; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Cardiology and Internal Medicine Department, Rede D'Or São Luiz, Rio de Janeiro 22281-100, Brazil., Tortelly MB; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Cardiology and Internal Medicine Department, Rede D'Or São Luiz, Rio de Janeiro 22281-100, Brazil., Pimentel AL; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Cardiology and Internal Medicine Department, Rede D'Or São Luiz, Rio de Janeiro 22281-100, Brazil., Figueiredo ACBS; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Cardiology and Internal Medicine Department, Rede D'Or São Luiz, Rio de Janeiro 22281-100, Brazil., Schaustz EB; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil., Secco JCP; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil., Fortier SC; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil., Vera N; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil., Conde L; Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil., Cabral-Castro MJ; Institute of Microbiology Paulo de Góes, UFRJ, Rio de Janeiro 21941-902, Brazil.; Department of Pathology, Faculty of Medicine, Fluminense Federal University, Niterói, Rio de Janeiro 24033-900, Brazil., Albuquerque DC; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Cardiology Department, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil., Rosado-de-Castro PH; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil., Pinheiro MVT; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Cardiology and Internal Medicine Department, Rede D'Or São Luiz, Rio de Janeiro 22281-100, Brazil., Souza OF; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Cardiology and Internal Medicine Department, Rede D'Or São Luiz, Rio de Janeiro 22281-100, Brazil., Luiz RR; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; Institute for Studies in Public Health-IESC, UFRJ, Rio de Janeiro 21941-598, Brazil., Medei E; D'Or Institute for Research and Education, Rio de Janeiro 22281-100, Brazil.; National Center for Structural Biology and Bioimaging, UFRJ, Rio de Janeiro 21941-902, Brazil.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2024 Dec 02; Vol. 13 (23). Date of Electronic Publication: 2024 Dec 02.
DOI: 10.3390/jcm13237317
Abstrakt: Cardiac involvement in 2019 coronavirus disease (COVID-19) survivors has been reported frequently. An exacerbated immune response may be the main mechanism of myocardial injury and late cardiac sequelae in this population. Background/Objectives: We investigated the immune profile in hypertensive and non-hypertensive patients with COVID-19 who developed late cardiac fibrosis and edema, as detected by magnetic resonance imaging (MRI). Methods: We evaluated associations of cytokine and immune-cell subset levels during hospitalization for COVID-19 with the presence of myocardial interstitial fibrosis [represented by the extracellular volume (ECV)] or edema (represented by the T2), detected by cardiac MRI examination after discharge, in hypertensive and non-hypertensive patients. Results: Patients with hypertension had reduced B-cell percentages, increased natural killer cell percentages, and higher interleukin (IL)-4, IL-5, IL-13, IL-17A, and tumor necrosis factor-β levels compared to patients without hypertension. Larger percentages of human leukocyte antigen DR isotope + blood cells, reflecting CD8+ T-cell activation, correlated with increased T2 and ECV in hypertensive patients. The HLA-DR mean fluorescence intensity was associated with ECV in non-hypertensive patients. Conclusions: Our findings reveal cytokine and immune-cell dysregulation in both hypertensive and non-hypertensive patients with COVID-19, along with moderate correlations between CD8+ T-cell activation and increased cardiac MRI markers of myocardial interstitial fibrosis and edema. These results contribute to a deeper understanding of immune dysfunction mechanisms involved in myocardial remodeling.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje