| Autor: |
Hsu TC; Department of Animal Science and Technology, National Taiwan University, Taipei 10672, Taiwan., Chiang CH; Department of Animal Science and Technology, National Taiwan University, Taipei 10672, Taiwan., Liu IH; Department of Animal Science and Technology, National Taiwan University, Taipei 10672, Taiwan., Wang CY; Department of Animal Science and Technology, National Taiwan University, Taipei 10672, Taiwan., Chen CY; Department of Animal Science and Technology, National Taiwan University, Taipei 10672, Taiwan. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of molecular sciences [Int J Mol Sci] 2024 Dec 09; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 09. |
| DOI: |
10.3390/ijms252313225 |
| Abstrakt: |
Weight regain within one year after weight loss is frequently observed and is referred to as yo-yo dieting or weight cycling. In this study, we explore the effects of yo-yo dieting on the liver, adipose tissue, and muscle characteristics of male zebrafish. Four-month-old AB wild-type male zebrafish were randomly assigned to three groups: high-calorie intake (H, seven meals per day), low-calorie intake (L, two meals per day), and yo-yo diet (the low- and high-calorie alternation switched every two weeks) groups. Feeding the fish the H diet for over 8 weeks led to steatosis and damage to the liver. The yo-yo diet reduced liver lipid accumulation at week eight but caused a similar degree of lipid accumulation as the H diet thereafter. It was found that twenty weeks of yo-yo dieting actually exacerbated hepatic damage. Compared to the L diet, feeding the fish on the yo-yo and H diets for a period of 20 weeks significantly increased the size of muscle fibers, resulting in higher speed during burst swimming and a significant increase in the size and number of adipocytes in the abdominal tissue. To summarize, short-term yo-yo dieting was found to attenuate hepatosteatosis and maintain fast-twitch muscle function. Long-term yo-yo dieting preserved fast-twitch muscle function and muscle fiber size; however, it exacerbated the pathological changes in the liver. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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