Microbiome-Based Therapeutics for Insomnia.

Autor: Li C; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Chen S; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Wang Y; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China., Su Q; Microbiota I-Center (MagIC), Hong Kong SAR, China.; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2024 Dec 09; Vol. 25 (23). Date of Electronic Publication: 2024 Dec 09.
DOI: 10.3390/ijms252313208
Abstrakt: Insomnia poses considerable risks to both physical and mental health, leading to cognitive impairment, weakened immune function, metabolic dysfunction, cardiovascular issues, and reduced quality of life. Given the significant global increase in insomnia and the growing scientific evidence connecting gut microbiota to this disorder, targeting gut microbiota as an intervention for insomnia has gained popularity. In this review, we summarize current microbiome-based therapeutics for insomnia, including dietary modifications; probiotic, prebiotic, postbiotic, and synbiotic interventions; and fecal microbiota transplantation. Moreover, we assess the capabilities and weaknesses of these technologies to offer valuable insights for future studies.
Databáze: MEDLINE