The Effectiveness and Safety of a Nutraceutical Combination in Overweight Patients with Metabolic Syndrome.
| Autor: | Ricottini L; Sinergheia Clinical Center, 00192 Rome, Italy., Basciani S; Department of Experimental Medicine, University 'Sapienza', 00161 Rome, Italy., Spizzichini ML; Department of Experimental Medicine, University 'Sapienza', 00161 Rome, Italy., de Mattia D; De Mattia Center for Nutrition and Obesity, 70124 Bari, Italy., Coniglio-Iannuzzi Delle Noci M; Delle Noci Multy Specialty Center, 70124 Bari, Italy., Sorrentino S; Villa Brasini Medical Center, 20100 Milan, Italy., Nordio M; Department of Experimental Medicine, University 'Sapienza', 00161 Rome, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Nutrients [Nutrients] 2024 Nov 21; Vol. 16 (23). Date of Electronic Publication: 2024 Nov 21. |
| DOI: | 10.3390/nu16233977 |
| Abstrakt: | Background: The aim of the present study was to evaluate the effectiveness and safety of a nutraceutical combination given to insulin-resistant overweight patients with altered lipid profiles. To this end, an observational study was designed in which 74 individuals (50 females and 24 males) underwent an observational period of 3 months. Methods: During this time, a specific nutraceutical combination containing myo-inositol, glycine, Coprinus comatus , α-lipoic acid, phlorizin, zinc, vitamin B 6 , and chromium picolinate was administered. Patients were asked not to modify their lifestyles so that no variable that might interfere with results was introduced. Results: After the 3-month period, the obtained data revealed that insulin levels significantly decreased with respect to the baseline, while glucose levels exhibited a trend towards lower concentrations, which was not significant. In addition, HOMA-IR index, body weight, BMI, and abdominal circumference values all decreased significantly. Regarding lipid profiles, the data obtained before and after the 3-month period showed statistically significant decreases in concentrations of total cholesterol, LDL cholesterol, and triglyceride, as well as a small but statistically significant concomitant increase in HDL cholesterol. Conclusions: Thus, on the basis of these data, it may be stated that the specific nutraceutical combination used in the present study significantly ameliorated a number of metabolic parameters without measurable side effects. The efficacy and safety of the product were, therefore, confirmed in our group of patients. |
| Databáze: | MEDLINE |
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