The Distribution and Predictive Factor of Extra-Pancreatic Malignancy Occurrence in Patients with Pancreatic Intraductal Papillary Mucinous Neoplasm-A Ten-Year Follow-Up Case-Control Study in Taiwan.

Autor: Wang SF; Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan., Wu CH; Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan., Sung KF; Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan., Tsou YK; Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan., Lin CH; Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan., Lee MH; Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan., Liu NJ; Department of Gastroenterology and Hepatology, Chang-Gung Memorial Hospital, Linkou Medical Center, Taoyuan 333, Taiwan.; School of Medicine, College of Medicine, Chang-Gung University, Taoyuan 333, Taiwan.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2024 Dec 07; Vol. 16 (23). Date of Electronic Publication: 2024 Dec 07.
DOI: 10.3390/cancers16234102
Abstrakt: Background and Aims: A higher incidence of extra-pancreatic malignancies (EPMs) in patients with pancreatic intraductal papillary mucinous neoplasm (IPMN) than in the general population has been shown in several studies. We suppose that EPMs also occur after IPMN has been diagnosed, but few reports have discussed the risk factors that have been identified, except for old age, which was only noted in one study. Our study aims to recognize the distribution of EPMs in Taiwanese patients with a longer duration of follow-up and investigate the risk factors to predict EPMs in IPMN patients.
Methods: We retrospectively analyzed 114 patients with pancreatic IPMN from 1 January 2010 to 31 December 2014 in Chang Gung Memorial Hospital. The characteristics of the patients were all recorded. Different EPMs are demonstrated as occurring before, concurrently with, or after IPMN diagnosis. The risk factors were compared between patients with or without an EPM.
Results: After an average follow-up duration of 10.45 years, 47 EPMs occurred in 42 patients (36.8%), and over half were found after IPMN was diagnosed (55.3%). The most common EPMs were colon cancer and lung cancer (21.3%). Moreover, cyst size progression was highly associated with EPM occurrence ( p = 0.004) and predictive of EPM occurrence after IPMN ( p = 0.002), with a cut-off value of 1 cm (accuracy: 79%; sensitivity: 88%; specificity: 58%).
Conclusions: Colon cancer and lung cancer account for the majority EPMs in Taiwan. EPMs were also frequently found after IPMN diagnosis when the follow-up duration was prolonged up to 10.45 years. Cyst size progression is a risk factor of EPM after IPMN diagnosis and we suggest a cut-off value of 1 cm for clinical utility.
Databáze: MEDLINE
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