Hypersine H, One Undescribed Xanthone from the Hypericum elodeoides Choisy with anti-neuroinflammation activity.

Autor: He S; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Liu X; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Wang T; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Li J; Xiamen University, School of pharmaceutical science, South Xiangan Road, Xiamen, Fujian 361102, China, xiamen, CHINA., Lin Y; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Zhou M; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Sun C; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Ding R; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Wang G; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA., Chen H; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Not Available, 361102, Xiamen, CHINA., Tian WJ; Xiamen University, School of Pharmaceutical Sciences, South Xiangan Road, Xiamen, Fujian 361102, China, Xiamen, CHINA.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Dec 16, pp. e202403037. Date of Electronic Publication: 2024 Dec 16.
DOI: 10.1002/cbdv.202403037
Abstrakt: One undescribed xanthone, hypersine H(1), together with three known analogues, 3,7-dihydroxy-1-methoxyxanthone (2), 1,7-dihydroxy-5,6-dimethoxyxanthone (3), 1,5-dihydroxy-6,7-dimethoxyxanthone (4), were isolated from the whole plant of Hypericum elodeoides Choisy. Their structures including absolute configurations were unambiguously elucidated by HR-ESI-MS, extensive NMR spectroscopy and quantum chemical calculation of ECD method. Moreover, the anti-neuroinflammation activities of isolated compounds were evaluated. As a result, compounds 1-2 decreased the production of nitric oxide(NO) in LPS-stimulated mouse BV2 microglia. Further mechanism study indicated that 1 and 2 exerted anti-neuroinflammation effects by suppressing the expression of pro-inflammatory enzymes including inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2. Above all, compounds 1-2 showed promise as useful therapeutic agents in the treatment of neurodegenerative diseases caused by neuroinflammation.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: