| Autor: |
Pokajewicz K; Faculty of Chemistry and Pharmacy, Opole University, pl. Kopernika 11a, 45-040 Opole, Poland., Biernat T; SynthPharm, ul. Witkacego 14, 96-100 Skierniewice, Poland., Wieczorek PP; Faculty of Chemistry and Pharmacy, Opole University, pl. Kopernika 11a, 45-040 Opole, Poland. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of natural products [J Nat Prod] 2024 Dec 27; Vol. 87 (12), pp. 2839-2846. Date of Electronic Publication: 2024 Dec 16. |
| DOI: |
10.1021/acs.jnatprod.4c01118 |
| Abstrakt: |
Linalyl anthranilate (LNA) has been identified in a number of plant extracts and essential oils by various authors using gas chromatography-mass spectrometry (GC-MS). However, the reported retention behavior of LNA in these studies is inconsistent with the retention data provided in the NIST database. Therefore, the objective of this study was to determine whether the reports of LNA were the result of misidentifications in GC-MS analyses or if the linear NIST retention index was inaccurate. To accomplish this, linalyl anthranilate was synthesized in a two-step procedure, and the resulting product was authenticated using nuclear magnetic resonance (NMR) and GC-MS analyses. This is a new synthetic route to linalyl anthranilate. Subsequently, retention indices for linalyl anthranilate were determined on three commonly used GC phases: polydimethylsiloxane, 5% diphenyl-95% polydimethylsiloxane, and polyethylene glycol. The study confirmed the accuracy of the NIST retention data, establishing the linear retention index data for LNA on a semi-nonpolar GC column as 2051. However, LNA reported in the literature by various authors exhibited a retention index in the elution window of approximately 1000-1400, strongly suggesting that these reports were the result of GC-MS misidentifications. A review of all reported occurrences of LNA in natural samples found no credible evidence of its presence. In many cases, it appears to be a misidentification of linalyl acetate caused by the occurrence of an erroneous spectrum in the older versions of the NIST mass spectra database. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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