Rates of colorectal cancer diagnosis and mortality in people with severe mental illness: results from Australia's National Bowel Cancer Screening Programme.

Autor:	Kisely S; Princess Alexandra Hospital Southside Clinical Unit, Greater Brisbane Clinical School, Medical School, The University of Queensland, Brisbane, QLD, Australia.; Metro South Addiction and Mental Health Service, Brisbane, QLD, Australia.; Departments of Psychiatry, Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada.; The ALIVE National Centre for Mental Health Research Translation, The University of Queensland, Brisbane, QLD, Australia., Spilsbury K; School of Public Health, Curtin University, Perth, Western Australia, Australia.; Institute for Health Research, University of Notre Dame Australia, Fremantle, Western Australia, Australia., Bull C; Princess Alexandra Hospital Southside Clinical Unit, Greater Brisbane Clinical School, Medical School, The University of Queensland, Brisbane, QLD, Australia.; The ALIVE National Centre for Mental Health Research Translation, The University of Queensland, Brisbane, QLD, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD, Australia., Jordan S; School of Public Health, University of Queensland, Brisbane, QLD, Australia.; Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Kendall BJ; Princess Alexandra Hospital Southside Clinical Unit, Greater Brisbane Clinical School, Medical School, The University of Queensland, Brisbane, QLD, Australia.; Department of Gastroenterology and Hepatology, Princess Alexandra Hospital, Brisbane, QLD, Australia., Siskind D; Princess Alexandra Hospital Southside Clinical Unit, Greater Brisbane Clinical School, Medical School, The University of Queensland, Brisbane, QLD, Australia.; Metro South Addiction and Mental Health Service, Brisbane, QLD, Australia.; Queensland Centre for Mental Health Research, The University of Queensland, Brisbane, QLD, Australia., Sara G; InforMH, System Information and Analytics Branch, NSW Ministry of Health, Sydney, QLD, Australia.; Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Protani M; School of Public Health, University of Queensland, Brisbane, QLD, Australia., Lawrence D; School of Public Health, Curtin University, Perth, Western Australia, Australia.
Jazyk:	angličtina
Zdroj:	Epidemiology and psychiatric sciences [Epidemiol Psychiatr Sci] 2024 Dec 17; Vol. 33, pp. e79. Date of Electronic Publication: 2024 Dec 17.
DOI:	10.1017/S2045796024000787
Abstrakt:	Aims: Studies show that people with severe mental illness (SMI) have a greater risk of dying from colorectal cancer (CRC). These studies mostly predate the introduction of national bowel cancer screening programmes (NBCSPs) and it is unknown if these have reduced disparity in CRC-related mortality for people with SMI. Methods: We compared mortality rates following CRC diagnosis at colonoscopy between a nationally representative sample of people with and without SMI who participated in Australia's NBCSP. Participation was defined as the return of a valid immunochemical faecal occult blood test (iFOBT). We also compared mortality rates between people with SMI who did and did not participate in the NBCSP. SMI was defined as receiving two or more Pharmaceutical Benefits Scheme prescriptions for second-generation antipsychotics or lithium. Results: Amongst NBCSP participants, the incidence of CRC in the SMI cohort was lower than in the controls (hazard ratio [HR] 0.77, 95% confidence interval [CI] 0.61-0.98). In spite of this, their all-cause mortality rate was 1.84 times higher (95% CI 1.12-3.03), although there was only weak evidence of a difference in CRC-specific mortality (HR 1.82; 95% CI 0.93-3.57). People with SMI who participated in the NBCSP had better all-cause survival than those who were invited to participate but did not return a valid iFOBT (HR 0.67, 95% CI 0.50-0.88). The benefit of participation was strongest for males with SMI and included improved all-cause and CRC-specific survival. Conclusions: Participation in the NBCSP may be associated with improved survival following a CRC diagnosis for people with SMI, especially males, although they still experienced greater mortality than the general population. Approaches to improving CRC outcomes in people with SMI should include targeted screening, and increased awareness about the benefits or participation. Trial Registration: Australian and New Zealand Clinical Trials Registry (Trial ID: ACTRN12620000781943).
Databáze:	MEDLINE
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