Potential of photodynamic therapy using polycationic photosensitizers in the treatment of lung cancer patients with SARS-CoV-2 infection and bacterial complications: our recent experience.

Autor: Meerovich GA; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia; Institute for Physics and Engineering in Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409 Moscow, Russia., Kogan EA; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia., Romanishkin ID; Prokhorov General Physics Institute of the Russian Academy of Sciences, 119991 Moscow, Russia., Zharkov NV; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia., Avraamova ST; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia., Shchelokova EE; I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow 119992, Russia., Akhlyustina EV; Institute for Physics and Engineering in Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409 Moscow, Russia., Strakhovskaya MG; Lomonosov Moscow State University, 119991 Moscow, Russia., Meerovich IG; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, 119071 Moscow, Russia., Demura SA; Institute for Physics and Engineering in Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409 Moscow, Russia., Tiganova IG; Lomonosov Moscow State University, 119991 Moscow, Russia., Romanova YM; Lomonosov Moscow State University, 119991 Moscow, Russia., Chen ZL; Huadong Hospital, Fudan University, Shanghai, 200040, China., Reshetov IV; Institute for Physics and Engineering in Biomedicine, National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409 Moscow, Russia.
Jazyk: angličtina
Zdroj: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2024 Dec 14, pp. 104447. Date of Electronic Publication: 2024 Dec 14.
DOI: 10.1016/j.pdpdt.2024.104447
Abstrakt: The problem of treating cancer patients with lung cancer has become more difficult due to the SARS-CoV-2 viral infection and concomitant bacterial lesions. The analysis shows that the photodynamic effect of long-wavelength polycationic photosensitizers suppresses the tumor process (including the destruction of cancer stem cells), SARS-CoV-2 coronavirus infection, Gram-positive and Gram-negative bacteria, including those that can cause pneumonia. Therefore, the photodynamic approach using such photosensitizers is promising for the development of an effective treatment method for patients with lung cancer, including those with SARS-CoV-2 infection and bacterial complications.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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